Basic information Safety Supplier Related

1-(2-CHLOROPHENYL)-N-METHYL-N-(1-METHYLPROPYL)-3-ISOQUINOLINECARBOXAMIDE

Basic information Safety Supplier Related

1-(2-CHLOROPHENYL)-N-METHYL-N-(1-METHYLPROPYL)-3-ISOQUINOLINECARBOXAMIDE Basic information

Product Name:
1-(2-CHLOROPHENYL)-N-METHYL-N-(1-METHYLPROPYL)-3-ISOQUINOLINECARBOXAMIDE
Synonyms:
  • 1-(2-chlorophenyl)-n-methyl-n-(1-methylpropyl)-3-isoquinolinecarboxamid
  • n-methyl-n-(1-methylpropyl)-1-(2-chlorophenyl)isoquinoline-3-carboxamide
  • 1-(2-CHLOROPHENYL)-N-METHYL-N-(1-METHYLPROPYL)-3-ISOQUINOLINECARBOXAMIDE
  • PK 11195
  • 1-(2-chlorophenyl)-N-methyl-*N-(1-methylpropyl)-3
  • PK 11195 PERIPHERAL BENZODIAZE
  • 1-(2-Chlorophenyl)-N-(1-methylpropyl)-3-isoquinolinecarboxamide
  • chlorophenylmethyl(1-methylpropyl)isoquinolinecarboxamide
CAS:
85532-75-8
MF:
C21H21ClN2O
MW:
352.86
Product Categories:
  • Miscellaneous Compounds
Mol File:
85532-75-8.mol
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1-(2-CHLOROPHENYL)-N-METHYL-N-(1-METHYLPROPYL)-3-ISOQUINOLINECARBOXAMIDE Chemical Properties

Boiling point:
511.7±45.0 °C(Predicted)
Density 
1.179±0.06 g/cm3(Predicted)
storage temp. 
Store at RT
form 
White crystalline powder.
pka
1.76±0.50(Predicted)
CAS DataBase Reference
85532-75-8(CAS DataBase Reference)
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Safety Information

WGK Germany 
3
RTECS 
NW6987000

MSDS

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1-(2-CHLOROPHENYL)-N-METHYL-N-(1-METHYLPROPYL)-3-ISOQUINOLINECARBOXAMIDE Usage And Synthesis

Uses

PK 11195 is a high affinity peripheral benzodiazepine receptor (PBR) ligand. PK 11195 has been shown to regulate protein phosphorylation in rat brain mitochondria under control of Ca2+. PK11195 promot es mitochondrial apoptosis and blocks P-glycoprotein (Pgp)-mediated drug efflux to chemosensitize cancer cells.

Definition

ChEBI: A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine

Biological Activity

Possesses high affinity for the MDR (peripheral benzodiazepine receptor) without binding to other known neurotransmitter receptors.

1-(2-CHLOROPHENYL)-N-METHYL-N-(1-METHYLPROPYL)-3-ISOQUINOLINECARBOXAMIDESupplier

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