1-Tetradecanol Chemical Properties

Melting point:

35-39 °C(lit.)

Boiling point:

289 °C(lit.)

Density 

0.823 g/mL at 25 °C(lit.)

vapor density 

7.4 (vs air)

vapor pressure 

<1 hPa (20 °C)

refractive index 

1.4454

Flash point:

>230 °F

storage temp. 

Store below +30°C.

solubility 

water: soluble0.00013g/L at 23°C

form 

Low Melting Solid, Crystalline Powder, Crystals, Flakes, Pellets and/or Chunks

pka

15.20±0.10(Predicted)

Specific Gravity

0.823

color 

White

Odor

fatty

Odor Type

waxy

Water Solubility 

insoluble

Merck 

14,6335

BRN 

1742652

Dielectric constant

4.4（48℃）

LogP

5.5

CAS DataBase Reference

112-72-1(CAS DataBase Reference)

NIST Chemistry Reference

1-Tetradecanol(112-72-1)

EPA Substance Registry System

1-Tetradecanol (112-72-1)

Safety Information

Hazard Codes 

Xi

Risk Statements 

38-36

Safety Statements 

24/25-26

RIDADR 

UN 3077 9 / PGIII

WGK Germany 

-

RTECS 

XB8655000

F 

9

Autoignition Temperature

489 °F

TSCA 

Yes

HS Code 

2905 19 00

HazardClass 

9

PackingGroup 

III

Hazardous Substances Data

112-72-1(Hazardous Substances Data)

Toxicity

LD50 orally in Rabbit: > 2000 mg/kg LD50 dermal Rabbit > 2000 mg/kg

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

1-Tetradecanol Usage And Synthesis

Description

1-Tetradecanol is a kind of straight-chain saturated fatty alcohol. It is often used as an ingredient in cosmetics such as cold creams because of its emollient properties. It can also be used as the intermediate during the manufacturing of some organic compounds like surfactants. Some studies have shown that it can inhibit the endothelial activation and reduce tissue responsiveness to cytokines, having the potential to treat the periodontitis based on studies on rabbits. It is also employed for the fabrication of temperature-regulated drug release system based on phase-change materials.

References

Lehmler, Hans-Joachim, and Paul M. Bummer. "Behavior of 10-(perfluorohexyl)-decanol, a partially fluorinated analog of hexadecanol, at the air–water interface." Journal of fluorine chemistry 117.1 (2002): 17-22.
Hasturk, Hatice, et al. "1-Tetradecanol complex reduces progression of porphyromonas gingivalis–induced experimental periodontitis in rabbits." Journal of periodontology 78.5 (2007): 924-932.
Hasturk, H, et al. "1-Tetradecanol complex: therapeutic actions in experimental periodontitis." Journal of Periodontology 80.7(2009): 1103-13.
Choi, Sung-Wook, Yu Zhang, and Younan Xia. "A temperature-sensitive drug release system based on phase-change materials." Angewandte Chemie International Edition 49.43 (2010): 7904-7908.

Chemical Properties

white low melting solid or flakes

Chemical Properties

Myristyl alcohol occurs as a white crystalline solid with a waxy odor. Also reported as opaque leaflets or crystals from ethanol.

Uses

myristyl alcohol is an emollient often used in hand creams, cold creams, and lotions to give them a smooth, velvety feel. Sources indicate it as being mildly comedogenic and potentially irritating.

Uses

1-Tetradecanol is used as an ingredient in cosmetics such as cold creams. It is an active intermediate in the chemical synthesis of sulfated alcohol. It is also employed in the fabrication of temperature-regulated drug release system based on phase-change materials. It plays a vital role in filling the hollow interiors of gold nanocages in the fabrication of new theranostic system, which has unique feature of photoacoustic imaging.

Uses

As emollient for cold creams, etc., also for making the sulfated alcohol whose sodium salt is applicable as a "wetter" in textiles.

Preparation

1-Tetradecanol is prepared from the head oil of the Sperm Whale via the acid and the ester.

Production Methods

Myristyl alcohol is found in spermaceti wax and sperm oil, and may be synthesized by sodium reduction of fatty acid esters or the reduction of fatty acids by lithium aluminum hydride. It can also be formed from acetaldehyde and dimethylamine.

Definition

ChEBI: 1-Tetradecanol is a long-chain fatty alcohol that is tetradecane in which one of the terminal methyl hydrogens is replaced by a hydroxy group It is a long-chain primary fatty alcohol, a fatty alcohol 14:0 and a primary alcohol.

Synthesis Reference(s)

The Journal of Organic Chemistry, 35, p. 1210, 1970 DOI: 10.1021/jo00829a089

General Description

Colorless thick liquid (heated) with a faint alcohol odor. Solidifies and floats on water.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

1-Tetradecanol is an alcohol. Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. They react with oxoacids and carboxylic acids to form esters plus water. Oxidizing agents convert them to aldehydes or ketones. Alcohols exhibit both weak acid and weak base behavior. They may initiate the polymerization of isocyanates and epoxides.

Health Hazard

Low toxicity. Overexposure causes some central nervous system depression. Prolonged skin contact causes skin irritation.

Flammability and Explosibility

Not classified

Pharmaceutical Applications

Myristyl alcohol is used in oral, parenteral, and topical pharmaceutical formulations. It has been evaluated as a penetration enhancer in melatonin transdermal patches in rats.
Myristyl alcohol has also been tested as a bilayer stabilizer in niosome formulations containing ketorolac tromethamine,and zidovudine.Niosomes containing myristyl alcohol showed a considerably slower release rate of ketorolac tromethamine than those containing cholesterol.This was also observed with the zidovudine formulation.

Safety

Myristyl alcohol is used in oral parenteral, and topical pharmaceutical formulations. The pure form of myristyl alcohol is mildly toxic by ingestion and may be carcinogenic; experimental tumorigenic data are available.It is also a human skin irritant. In animal studies of the skin permeation enhancement effect of saturated fatty alcohols, myristyl alcohol exhibited a lower effect when compared with decanol, undecanol, or lauryl alcohol but caused greater skin irritation.A study investigating contact sensitization to myristyl alcohol revealed that patch testing of myristyl alcohol 10% petrolatum should not be carried out owing to observed irritant effects; thus the use of a lower concentration of myristyl alcohol for such tests (5% petrolatum) was recommended.Myristyl alcohol has been associated with some reports of contact allergy.(8,9)A moderate-to-severe erythema and moderate edema are seen when 75 mg is applied to human skin intermittently in three doses over 72 hours.
LD₅₀(rabbit, skin): 7.1 g/kg
LD₅₀(rat, oral): 33.0 g/kg

storage

The bulk material should be stored in a well-closed container in a cool, dry place.

Purification Methods

Crystallise the alcohol from aqueous EtOH. It has also been purified by zone melting. [Beilstein 1 IV 1864.]

Incompatibilities

Myristyl alcohol is combustible when exposed to heat or flame. It can react with oxidizing materials. When heated to decomposition, it emits acrid smoke and irritating fumes.

Regulatory Status

Included in the FDA Inactive Ingredients Database (oral tablet: sustained-release; and topical formulations: cream, lotion, suspension). Included in nonparenteral (topical cream) formulations licensed in the UK.

1-Tetradecanol(112-72-1)Related Product Information

• Ethyl acetate
• Erythritol
• Myristic acid
• TRIMYRISTIN
• Myristicin
• MONOMYRISTIN
• TETRADECANOL
• Lauryl/MyristylAlcohol
• 2,6-Diacetylpyridine
• HEXADECANEDIOIC ACID
• OCTADECANOIC ACID-1-13C
• AGARIC ACID
• 2,6-Pyridinedicarboxaldehyde
• PENTADECANOIC ACID
• 2,6-Pyridinedicarboxylic acid chloride
• Arachidic acid
• HEXADECANOIC ACID-1-13C
• NONADECANOIC ACID