1a,1b,2,3,4,5,7a,8,8a,9,10,10a-Dodecahydro-2-hydroxy-6-(hydroxymethyl) -3,8,8,10a-tetramethyl-5-oxo-4aH-cyclopenta(3,4)cyclopropa(8,9)cycloun dec(1,2-b)oxiren-4a-yl ester Chemical Properties

Boiling point:

643.1±55.0 °C(Predicted)

Density 

1.25±0.1 g/cm3(Predicted)

solubility 

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

form 

Powder

pka

13.55±0.10(Predicted)

1a,1b,2,3,4,5,7a,8,8a,9,10,10a-Dodecahydro-2-hydroxy-6-(hydroxymethyl) -3,8,8,10a-tetramethyl-5-oxo-4aH-cyclopenta(3,4)cyclopropa(8,9)cycloun dec(1,2-b)oxiren-4a-yl ester Usage And Synthesis

Uses

Jolkinol A is a natural product that can be found in Euphorbia pubescens. Jolkinol A inhibits cell growth with GI50s of 95.3, 57.3, >100 μM for MCF-7, NCI-460, SF-268 cells, respectively[1].

Definition

ChEBI: A lathyrane diterpenoid isolated from the roots of Euphorbia micractina.

References

[1] Valente C, et al. Euphopubescenol and euphopubescene, two new jatrophane polyesters, and lathyrane-type diterpenes from Euphorbia pubescens. Planta Med. 2004 Mar;70(3):244-9. DOI:10.1055/s-2004-815542

1a,1b,2,3,4,5,7a,8,8a,9,10,10a-Dodecahydro-2-hydroxy-6-(hydroxymethyl) -3,8,8,10a-tetramethyl-5-oxo-4aH-cyclopenta(3,4)cyclopropa(8,9)cycloun dec(1,2-b)oxiren-4a-yl ester(62820-11-5)Related Product Information

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