2-(TRIMETHYLSILYL)ETHOXYMETHYLTRIPHENYLPHOSPHONIUM CHLORIDE
2-(TRIMETHYLSILYL)ETHOXYMETHYLTRIPHENYLPHOSPHONIUM CHLORIDE Basic information
- Product Name:
- 2-(TRIMETHYLSILYL)ETHOXYMETHYLTRIPHENYLPHOSPHONIUM CHLORIDE
- Synonyms:
-
- SEM-TRIPHENYLPHOSPHONIUM CHLORIDE
- 2-(TRIMETHYLSILYL)ETHOXYMETHYLTRIPHENYLPHOSPHONIUM CHLORIDE
- -(Trimethylsilyl)ethoxymethyl-triphenylphosphonium chloride
- 2-(trime-silyl)ethoxymethyl-triphenyl-phosphonium chloride
- PHENYL PHOSPHONIUM CHLORIDE
- [2-(trimethylsily)ethoxymethyl]triphenylphosphonium.Cl
- 2-(Trimethylsilyl)ethoxymethyl-triphenylphosphonium chloride,SEM-triphenylphosphonium chloride
- triphenyl(2-trimethylsilylethoxymethyl)phosphanium:chloride
- CAS:
- 82495-75-8
- MF:
- C24H30ClOPSi
- MW:
- 429.01
- Product Categories:
-
- Wittig Reaction
- Phosphonium Compounds
- Si (Classes of Silicon Compounds)
- Si-(C)4 Compounds
- Silicon Compounds (for Synthesis)
- Synthetic Organic Chemistry
- Wittig & Horner-Emmons Reaction
- Mol File:
- 82495-75-8.mol
2-(TRIMETHYLSILYL)ETHOXYMETHYLTRIPHENYLPHOSPHONIUM CHLORIDE Chemical Properties
- Melting point:
- 145-149 °C(lit.)
- storage temp.
- Sealed in dry,2-8°C
- solubility
- Sol H2O and dichloromethane; sparingly soluble in THF.
- form
- powder to crystal
- color
- White to Almost white
- BRN
- 4632507
- CAS DataBase Reference
- 82495-75-8(CAS DataBase Reference)
MSDS
- Language:English Provider:SigmaAldrich
2-(TRIMETHYLSILYL)ETHOXYMETHYLTRIPHENYLPHOSPHONIUM CHLORIDE Usage And Synthesis
Physical properties
mp 165–169 °C.
Uses
2-(Trimethylsilyl)ethoxymethyltriphenylphosphonium Chloride is used in preparation of Benzodecalindiones as antitumor agents.
Uses
[2-(Trimethylsilyl)ethoxymethyl]- triphenylphosphonium chloride is a reagent undergoes deprotonation and yield formation permitting the construction of enol ethers from aldehydes and ketones.
Preparation
Involves reaction of triphenylphosphine with 2-(trimethylsilyl)ethoxymethyl chloride in benzene at gentle reflux for 18 h. Upon cooling, the resulting phosphonium salt can be recovered by filtration and purified by triturating with diethyl ether in 94% yield.
Purification Methods
Wash the solid with AcOH and recrystallise it from CH2Cl2/EtOAc. Dry it in a vacuum desiccator. Hygroscopic. 1H NMR (CDCl3) : -0.2 (s, Me3Si), 0.8 (t, 8Hz, CH2Si), 3.83 (t, 8Hz, OCH2), 5.77 (d, JPH 4Hz, P+-CH2O) and 7.70 (m, aromatic H). [Sch.nauer & Zbiral Justus Liebigs Ann Chem 1039 1983.]
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2-(TRIMETHYLSILYL)ETHOXYMETHYLTRIPHENYLPHOSPHONIUM CHLORIDE(82495-75-8)Related Product Information
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- 2-(TRIMETHYLSILYL)ETHOXYMETHYLTRIPHENYLPHOSPHONIUM CHLORIDE
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