(Methoxymethyl)triphenylphosphonium chloride Chemical Properties

Melting point:

185-195 °C (dec.)(lit.)

bulk density

450-500kg/m3

vapor pressure 

<1 hPa ( 20 °C)

Flash point:

>250°C

storage temp. 

Store below +30°C.

solubility 

>1100g/l soluble,(decomposition)

form 

Crystalline Powder

color 

White to almost white

PH

2.2 (1100g/l, H2O, 20℃)

Water Solubility 

decomposes

Sensitive 

Hygroscopic

BRN 

924215

InChIKey

SJFNDMHZXCUXSA-UHFFFAOYSA-M

LogP

-1.17

CAS DataBase Reference

4009-98-7(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

22-36/37/38

Safety Statements 

26-36-24/25

RIDADR 

UN 1390 4.3/PG 2

WGK Germany 

3

F 

3-10

Hazard Note 

Harmful

HS Code 

29310095

MSDS

• Language:English Provider:(Methoxymethyl)triphenylphosphonium chloride
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

(Methoxymethyl)triphenylphosphonium chloride Usage And Synthesis

Chemical Properties

WHITE TO ALMOST WHITE FINE CRYSTALLINE POWDER

Uses

(Methoxymethyl)triphenylphosphonium chloride is used as a phase transfer catalyst and in the synthesis of taxol-A fragment. It is widely used in the synthesis of pharmaceutical product cephalotaxine, which is used as an antiviral and antitumor agent.

Uses

Intermediates of Liquid Crystals

Uses

PTC catalyst

reaction suitability

reaction type: C-C Bond Formation

Synthesis

The general procedure for the synthesis of (methoxymethyl)triphenylphosphonium chloride from chloromethyl methyl ether and triphenylphosphine was as follows: 20.0 g of triphenylphosphine was placed in a round-bottomed flask, dissolved in an appropriate amount of toluene, and heated to 95°C. The reaction was carried out at a constant temperature for 16 hours. Subsequently, 6.37 mL of chloromethyl methyl ether was slowly added dropwise and the reaction was kept at temperature for 16 hours. Upon completion of the reaction, the reaction mixture was cooled to room temperature and the solid product was collected by filtration. The filter cake was washed three times with toluene to remove impurities and then dried to give 25.4 g of white phosphonium salt in 97.3% yield.

References

[1] Synthesis (Germany), 2013, vol. 45, # 5, p. 596 - 600
[2] Patent: CN107936009, 2018, A. Location in patent: Paragraph 0042; 0087-0088
[3] Bulletin of the Chemical Society of Japan, 1980, vol. 53, # 12, p. 3436 - 3438
[4] Patent: CN106588982, 2017, A. Location in patent: Paragraph 0008; 0017; 0018; 0019; 0020; 0021; 0022-0025
[5] Journal of the American Chemical Society, 1976, vol. 98, p. 6613 - 6623

(Methoxymethyl)triphenylphosphonium chloride(4009-98-7)Related Product Information

• 4-Methoxyphenylacetone
• Methyltriphenylphosphonium bromide
• Zinc chloride
• Trimethylphenylammonium chloride
• 2,3,5-Triphenyltetrazolium chloride
• Chlorodiphenylphosphine
• Sodium chloride
• Oxalyl chloride
• Thionyl chloride
• Choline chloride
• Calcium chloride
• Ammonium chloride
• Potassium chloride
• Tris(triphenylphosphine)chlororhodium
• Methylene Chloride
• (FORMYLMETHYLENE)TRIPHENYLPHOSPHORANE
• HYDROXYMETHYL TRIPHENYLPHOSPHONIUM CHLORIDE
• 2-(TRIMETHYLSILYL)ETHOXYMETHYLTRIPHENYLPHOSPHONIUM CHLORIDE