marinobufagenin Chemical Properties

Melting point:

224-225 °C

Boiling point:

589.0±50.0 °C(Predicted)

Density 

1.31±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMF: 3 mg/ml; DMF:PBS (pH 7.2) (1:8): 0.1 mg/ml; Ethanol: 1 mg/ml

form 

A crystalline solid

pka

14.77±0.70(Predicted)

marinobufagenin Usage And Synthesis

Uses

Marinobufagin is a bufadienolide with anti-gastric cancer effect. A bioactive steroid that also functions as an endogenous Na/K-ATPase bufadienolide inhibitor that plays a major role in human cardiovascular diseases.

Definition

ChEBI: Marinobufagenin is a cardiotonic steroid secreted by the toad Bufo rubescens and other related species such as Bufo marinus. An endogenous Na/K-ATPase inhibitor, it is a vasoconstrictor with effects similar to digitalis. It has a role as an EC 3.6.3.9 (Na(+)/K(+)-transporting ATPase) inhibitor and an epitope. It is a steroid hormone and an epoxy steroid. It is functionally related to a (5beta)-bufadienolide.

marinobufagenin(470-42-8)Related Product Information

• 3':5'-CYCLIC-NUCLEOTIDE 5'-NUCLEOTIDOHYDROLASE
• ECHISTATIN
• PHOSPHOLIPASE A2
• MASTOPARAN 17
• VAL-ASP-TRP-LYS-LYS-ILE-GLY-GLN-HIS-ILE-LEU-SER-VAL-LEU-NH2
• MU-CONOTOXIN GIIIA
• Desacetylcinobufagin
• 19-Hydroxybufalin
• MAS 7
• Bufalin
• arenobufagin
• MASTOPARAN X
• Desacetylcinobufotalin
• ENTEROTOXIN STP (E COLI)
• MAST CELL DEGRANULATING PEPTIDE HR-2
• CHLOROTOXIN
• SHK
• NA