3':5'-CYCLIC-NUCLEOTIDE 5'-NUCLEOTIDOHYDROLASE Chemical Properties

storage temp. 

-20°C

form 

lyophilized powder

Safety Information

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

3':5'-CYCLIC-NUCLEOTIDE 5'-NUCLEOTIDOHYDROLASE Usage And Synthesis

Uses

For use in calmodulin (P 0270) assay. Activity is reduced to <50% without calmodulin present.

Uses

Phosphodiesterase, 3′,5′-cyclic-nucleotide-specific from bovine brain has been used to assay the protein activator, calmodulin and in in vitro adenylate cyclase assay.

General Description

Phosphodiesterase (PDE1) exists in two isoforms -PDE1A2 and PDE1B1. The enzyme has a role in the complex interaction between cyclic nucleotides and Ca²⁺ second-messenger systems.

Biochem/physiol Actions

Hydrolyzes the 3′,5′-phosphodiester bond in cyclic nucleotide monophosphates, such as cAMP and cGMP, to the corresponding nucleotide 5′-monophosphate.

Clinical Use

Phosphodiesterase-3 (PDE3) is an enzyme responsible for degradation of cAMP to AMP in platelets and blood vessels. Selective cAMP PDE3 inhibitors, such as dipyridamole and cilostazol , inhibit the degradation of cAMP, thereby increasing cellular concentration of cAMP and leading to inhibition of platelet aggregation and vasodilation.

3':5'-CYCLIC-NUCLEOTIDE 5'-NUCLEOTIDOHYDROLASE(9040-59-9)Related Product Information

• Benzyl isocyanide
• DICHLORO(ETHYLENEDIAMINE)PLATINUM(II)
• 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE
• Tris(2,4-pentanedionato)chroMiuM(III)
• TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III)
• Cupric acetylacetonate
• Ethyl isocyanoacetate
• Aluminum acetylacetonate
• METHYL ISOCYANOACETATE
• SALCOMINE
• 2,4-PENTANEDIONE, SILVER DERIVATIVE
• Ferric acetylacetonate
• N-BUTYLISOCYANIDE
• Tosylmethyl isocyanide
• PHENYLSELENOL
• COBALT(II) ACETYLACETONATE
• TERT-BUTYL ISOCYANIDE
• TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III)