PHALLACIDIN
PHALLACIDIN Basic information
- Product Name:
- PHALLACIDIN
- Synonyms:
-
- 5-DIHYDROXY-LEU-VAL-ERYTHRO-3-HYDROXY-D-ASP-CYS-CIS-4-HYDROXY-PRO)
- CYCLO(ALA-2-MERCAPTO-TRP-4
- PHALLACIDIN FROM AMANITA PHALLOIDES;CYCLO(ALA-2-MERCAPTO-TRP-4;5-DIHYDROXY-LEU-VAL-ERYTHRO-3-HYDROXY-D-ASP-CYS-CIS-4-HYDROXY-PRO)
- 5-
Dihydroxy- Leu- Val-erythro-3-Hydroxy- D -Asp-Cys-cis-4-Hydroxy-Pro) - Cyclo(Ala-
2- Mercapto- Trp- 4 - PHALLACIDIN FROM AMANITA PHALLOIDES;CYCLO(ALA-
2- MERCAPTO- TRP- 4;5- DIHYDROXY- LEU- VAL-ERYTHRO-3-HYDROXY- D -ASP-CYS-CIS-4-HYDROXY-PRO) - PHALLACIDIN
- PHALLICIDIN
- CAS:
- 26645-35-2
- MF:
- C37H50N8O13S
- MW:
- 846.9
- Product Categories:
-
- marker
- Mol File:
- 26645-35-2.mol
PHALLACIDIN Chemical Properties
- Density
- 1.1678 (rough estimate)
- refractive index
- 1.7400 (estimate)
- solubility
- DMF: Soluble; DMSO: Soluble; Methanol: Soluble; Water: Soluble
- form
- White to off-white powder.
- color
- White to off-white
Safety Information
- Hazard Codes
- T+
- Risk Statements
- 26/27/28
- Safety Statements
- 22-36/37/39-45
- RIDADR
- 1544
- WGK Germany
- 3
- RTECS
- GT8943000
- HazardClass
- 6.1(a)
- PackingGroup
- I
- HS Code
- 2934999090
PHALLACIDIN Usage And Synthesis
Description
Phallacidin is a natural mycotoxin first isolated from the death cap mushroom, A. phalloides. It binds filamentous actin (F-actin) like phalloidin , but contains a carboxyl group for coupling reactions.
Uses
Toxin Phallacidin is a weak fluorescent bicyclic peptide probe in aquous solution, Which is isolated from Amanita phalloides mushroom and could be used for blocking F-actin staining by labeled phallotoxins, which promotes actin polymerization.
Uses
Phallacidin is a natural mycotoxin first isolated from the death cap mushroom. It binds filamentous actin like phalloidin.
Definition
ChEBI: A homodetic bicyclic heptapeptide having a sulfide bridge.
Biochem/physiol Actions
Phallacidin, which is a bicyclic toxin from the Amanita phalloides mushroom, has been shown to inhibit F-actin degradation by proteolytic enzymes including trypsin and α-chymotrypsin.
Enzyme inhibitor
This cyclic heptapeptide toxin (FWfree-acid = 846.92 g/mol; CAS 26645-35-2) from the poisonous green fungus Amanita phalloides stabilizes actin filaments and inhibits actin filament depolymerization. NBD phallacidin is a high-affinity, filamentous actin probe consisting of rabbit actin that is conjugated by reacting its thiol group with 4-chloro-7- nitrobenzofurazan, a yellow-green fluorescent dye. NBD phallacidin (Excitation at 465 nm; Emission at 536 nm) selectively stains F-actin un a manner that is superior to antibody staining, preferably in fixed and permeabilized samples. See Phalloidin
PHALLACIDINSupplier
- Tel
- 400-400-6206333 18521732826
- market@aladdin-e.com
- Tel
- 021-51320588
- tauto@tautobiotech.com
- Tel
- 021-61415566 800-8193336
- orderCN@merckgroup.com
- Tel
- 021-65675885 18964387627
- info@efebio.com
- Tel
- 400-1166-196 18502815961
- cdhxsj@163.com
PHALLACIDIN(26645-35-2)Related Product Information
- 3-AMINO-PENTANOIC ACID
- PENTAETHYLENEHEXAMINE
- 5-Aminolevulinic acid
- (R)-Isoserine
- 1,4,7,10,13-Pentaazatridecane
- (S)-3-Hydroxypyrrolidine
- DL-Isoserine
- Dibutylurea
- 1-Methyl-3-pyrrolidinol
- AC-TRP-NH2
- 4-Methylthio-2-butanone
- (2S,3S)-3-AMINO-2-HYDROXYHEXANOIC ACID
- (S)-3-Aminopentanoic acid
- PYRROLIDINE-1-CARBOXYLIC ACID AMIDE
- (S)-(+)-1-Methyl-3-pyrrolidinol
- L-TRP-GLY AMIDE
- PHALLACIDIN
- 1-AMINO-4-HYDROXY-BUTAN-2-ONE