Basic information Safety Supplier Related

PHALLACIDIN

Basic information Safety Supplier Related

PHALLACIDIN Basic information

Product Name:
PHALLACIDIN
Synonyms:
  • 5-DIHYDROXY-LEU-VAL-ERYTHRO-3-HYDROXY-D-ASP-CYS-CIS-4-HYDROXY-PRO)
  • CYCLO(ALA-2-MERCAPTO-TRP-4
  • PHALLACIDIN FROM AMANITA PHALLOIDES;CYCLO(ALA-2-MERCAPTO-TRP-4;5-DIHYDROXY-LEU-VAL-ERYTHRO-3-HYDROXY-D-ASP-CYS-CIS-4-HYDROXY-PRO)
  • 5-Dihydroxy-Leu-Val-erythro-3-Hydroxy-D-Asp-Cys-cis-4-Hydroxy-Pro)
  • Cyclo(Ala-2-Mercapto-Trp-4
  • PHALLACIDIN FROM AMANITA PHALLOIDES;CYCLO(ALA-2-MERCAPTO-TRP-4;5-DIHYDROXY-LEU-VAL-ERYTHRO-3-HYDROXY-D-ASP-CYS-CIS-4-HYDROXY-PRO)
  • PHALLACIDIN
  • PHALLICIDIN
CAS:
26645-35-2
MF:
C37H50N8O13S
MW:
846.9
Product Categories:
  • marker
Mol File:
26645-35-2.mol
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PHALLACIDIN Chemical Properties

Density 
1.1678 (rough estimate)
refractive index 
1.7400 (estimate)
solubility 
DMF: Soluble; DMSO: Soluble; Methanol: Soluble; Water: Soluble
form 
White to off-white powder.
color 
White to off-white
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Safety Information

Hazard Codes 
T+
Risk Statements 
26/27/28
Safety Statements 
22-36/37/39-45
RIDADR 
1544
WGK Germany 
3
RTECS 
GT8943000
HazardClass 
6.1(a)
PackingGroup 
I
HS Code 
2934999090
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PHALLACIDIN Usage And Synthesis

Description

Phallacidin is a natural mycotoxin first isolated from the death cap mushroom, A. phalloides. It binds filamentous actin (F-actin) like phalloidin , but contains a carboxyl group for coupling reactions.

Uses

Toxin Phallacidin is a weak fluorescent bicyclic peptide probe in aquous solution, Which is isolated from Amanita phalloides mushroom and could be used for blocking F-actin staining by labeled phallotoxins, which promotes actin polymerization.

Uses

Phallacidin is a natural mycotoxin first isolated from the death cap mushroom. It binds filamentous actin like phalloidin.

Definition

ChEBI: A homodetic bicyclic heptapeptide having a sulfide bridge.

Biochem/physiol Actions

Phallacidin, which is a bicyclic toxin from the Amanita phalloides mushroom, has been shown to inhibit F-actin degradation by proteolytic enzymes including trypsin and α-chymotrypsin.

Enzyme inhibitor

This cyclic heptapeptide toxin (FWfree-acid = 846.92 g/mol; CAS 26645-35-2) from the poisonous green fungus Amanita phalloides stabilizes actin filaments and inhibits actin filament depolymerization. NBD phallacidin is a high-affinity, filamentous actin probe consisting of rabbit actin that is conjugated by reacting its thiol group with 4-chloro-7- nitrobenzofurazan, a yellow-green fluorescent dye. NBD phallacidin (Excitation at 465 nm; Emission at 536 nm) selectively stains F-actin un a manner that is superior to antibody staining, preferably in fixed and permeabilized samples. See Phalloidin

PHALLACIDINSupplier

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