phellopterin Chemical Properties

Melting point:

102-103℃

Boiling point:

480.4±45.0 °C(Predicted)

Density 

1.243

storage temp. 

Store at -20°C

solubility 

Soluble in acetonitrile and chloroform

form 

powder

color 

Light yellow

LogP

2.867 (est)

phellopterin Usage And Synthesis

Description

Phellopterin is a commonly used yin-nourishing medicine in clinical practice. Indications: Dryness of the lungs, dry cough, fever injury, thirst and other symptoms. It is found that the preparation methods of coralline mostly use organic reagent extraction and silica gel column separation.

Uses

Phellopterin is a natural product isolated from Angelica dahurica. Phellopterin reduces TNF-alpha-induced VCAM-1 expression through regulation of the Akt and PKC pathway, which contributes to inhibit the adhesion of monocytes to endothelium[1].

Definition

ChEBI: Phellopterin is a member of psoralens.

Biological Activity

Phellopterin is a natural product isolated from P. trifoliata. It inhibits monocyte-endothelial cell adhesion by reducing TNF-alpha-induced VCAM-1 expression by regulating Akt and PKC pathways.

References

[1] Nizamutdinova IT, et al. Hesperidin, hesperidin methyl chalone and phellopterin from Poncirus trifoliata (Rutaceae) differentially regulate the expression of adhesion molecules in tumor necrosis factor-alpha-stimulated human umbilical vein endothelial cells. Int Immunopharmacol. 2008 May;8(5):670-8. DOI:10.1016/j.intimp.2008.01.011

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