2-(4-HYDROXY-3-METHOXYPHENYL)BENZOTHIAZOLE
2-(4-HYDROXY-3-METHOXYPHENYL)BENZOTHIAZOLE Basic information
- Product Name:
- 2-(4-HYDROXY-3-METHOXYPHENYL)BENZOTHIAZOLE
- Synonyms:
-
- 2-(4-HYDROXY-3-METHOXYPHENYL)BENZOTHIAZOLE
- YL-109
- 4-(benzo[d]thiazol-2-yl)-2-Methoxyphenol
- Y109
- Y-109
- Y-109;Y109
- 4-(3H-1,3-benzothiazol-2-ylidene)-2-methoxycyclohexa-2,5-dien-1-one
- 4-(1,3-Benzothiazol-2-yl)-2-methoxyphenol
- CAS:
- 36341-25-0
- MF:
- C14H11NO2S
- MW:
- 257.31
- Product Categories:
-
- Inhibitors
- Mol File:
- 36341-25-0.mol
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2-(4-HYDROXY-3-METHOXYPHENYL)BENZOTHIAZOLE Chemical Properties
- storage temp.
- 2-8°C
- solubility
- DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:9): 0.1 mg/ml; Ethanol: 1 mg/ml
- form
- A crystalline solid
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2-(4-HYDROXY-3-METHOXYPHENYL)BENZOTHIAZOLE Usage And Synthesis
Biological Activity
YL-109 is a novel antitumor agent that inhibits the growth and invasion of breast cancer cells in vitro and in vivo.
in vitro
YL-109 (0.001-10 μM; 96 h or 24 h) inhibits cell proliferation, motility, and invasiveness in breast cancer cells.
YL-109 (1 μM) increases both CHIP mRNA and protein levels in MDA-MB-231 cells.
Cell Proliferation Assay
| Cell Line: | < td class="col2"> MCF-7 and MDA-MB-231 cells|
| Concentration: | 0.001, 0.01, 0.1, 1, 10 μM |
| Incubation Time: | 96 hours |
| Result: | Strongly inhibited cell proliferation of MCF-7 and MDA-MB-231 cells in a dose-dependent manner (IC 50 =85.8 nM and 4.02 μM, respectively). |
in vivo
YL-109 (15 mg/kg; sc for every 2 d) inhibits both tumor growth and cancer metastasis of breast cancer cells in vivo.
< /p>
| Animal Model: | BALB/cAjcl-nu/nu female mice (4-5 weeks) inoculated with MCF-7 or MDA-MB-231 cells |
| Dosage: | 15 mg/kg |
| Administration: < /td> | Sc every 2 days for 63 days |
| Result: | Suppressed tumor growth in mice injected with MCF-7 and MDA-MB-231 cells. |
2-(4-HYDROXY-3-METHOXYPHENYL)BENZOTHIAZOLESupplier
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