(+)-Taddol Chemical Properties

Melting point:

193-196 °C(lit.)

alpha 

-62.6 º (c=1 in chloroform)

Boiling point:

633.2±50.0 °C(Predicted)

Density 

1.200±0.06 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Room Temperature

form 

powder to crystal

pka

12.28±0.29(Predicted)

color 

White to Almost white

optical activity

[α]19/D +67°, c = 1 in chloroform

BRN 

4724097

InChIKey

RNSJHECWLNVNFE-LOYHVIPDSA-N

CAS DataBase Reference

93379-49-8(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn

Risk Statements 

20/21/22-36/37/38

Safety Statements 

26-36

WGK Germany 

3

HS Code 

29329990

MSDS

• Language:English Provider:SigmaAldrich

(+)-Taddol Usage And Synthesis

Chemical Properties

white to light yellow crystal powde

Uses

Ligand for enantioselective Lewis-acid mediated Diels-Alder, allyltitanation of aldehydes, and Michael-Mukaiyama additions promoted by chiral Ti-complexes.

Preparation

Preparative Methods of (4R,5R)-2,2-Dimethyl-4,5-bis(hydroxydiphenylmethyl)-1,3-dioxolane: chiral titanates are usually prepared by mixing dichlorodiisopropoxytitanium and a chiral 1,4-diol in toluene. Other solvents such as ether and dichloromethane can also be employed. The alcohol exchange reaction takes place immediately at rt. Wherever necessary, liberated isopropyl alcohol is removed by azeotropic removal with toluene. The chiral 1,4-diols are prepared from dimethyl (or diethyl) tartrate by a two-step procedure comprising acetalization followed by the addition of an aryl Grignard reagent.

storage

Chiral titanates are usually prepared just before use under argon atmosphere. Care should be taken to avoid moisture, especially when a catalytic amount of the reagent is used.

(+)-Taddol(93379-49-8)Related Product Information

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• Dimethyl sulfide
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• Dimethyl ether
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• ETHANE
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