CHEMPACIFIC 38132 Chemical Properties

Boiling point:

332.2±22.0 °C(Predicted)

Density 

1.375±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

pka

-3.24±0.10(Predicted)

CHEMPACIFIC 38132 Usage And Synthesis

Synthesis

General procedure for the synthesis of methyl 4-nitropyridinecarboxylate from methanol and 4-nitro-2-pyridinecarboxylic acid: firstly, esterification of 4-nitro-2-pyridinecarboxylic acid was carried out in anhydrous methanol by reacting with concentrated sulfuric acid as a catalyst at 25 °C for 18 h. Methyl 4-nitropyridinecarboxylate (1f) was obtained in 65% yield. Subsequently, a mixed solution of methyl 4-nitro-2-pyridinecarboxylate (1f) (1.0 g, 6.62 mmol) with acetone (0.195 mL, 2.65 mmol) in DME (5 mL) was slowly added dropwise to a stirred NaH suspension (60% oil suspension, 0.5 g, 13.23 mmol in DME 5 mL), and the reaction was carried out at room temperature under argon protection. The reaction was carried out at room temperature under argon protection. The reaction mixture was stirred at 30 °C for 2 h or 18 h and then refluxed for 2 h, during which no gas escape was observed. The feedstock was recovered during reprocessing.

References

[1] Tetrahedron, 2014, vol. 70, # 45, p. 8520 - 8531

CHEMPACIFIC 38132(29681-41-2)Related Product Information

• CHEMPACIFIC 38139
• CHEMPACIFIC 38132
• 4-NITROPICOLINIC ACID
• Methyl 4-aminopyridine-2-carboxylate
• 4-Aminopyridine-2-carboxylic acid
• SPECS AC-907/25005407
• 2-Methyl-4-nitropyridine