Basic information Safety Supplier Related
ChemicalBook >  Product Catalog >  Chemical Reagents >  Organic reagents >  Nitro compounds >  4-Nitrophthalic anhydride

4-Nitrophthalic anhydride

Basic information Safety Supplier Related

4-Nitrophthalic anhydride Basic information

Product Name:
4-Nitrophthalic anhydride
Synonyms:
  • 5-NITRO-ISOBENZOFURAN-1,3-DIONE
  • TIMTEC-BB SBB008431
  • 1,3-Isobenzofurandione, 5-nitro-
  • 4-Nitrophthalic acid anhydride
  • 4-nitrophthalicacidanhydride
  • 4-NITROPHTHALIC ANHYDRIDE
  • 4-Nitro Phthalic Anhydride p-Nitro Phthalic Anhydride
  • 4-Nitrophthalicanhydride,95%
CAS:
5466-84-2
MF:
C8H3NO5
MW:
193.11
EINECS:
226-776-2
Product Categories:
  • Aromatics
  • Heterocycles
  • Carboxylic Acid Anhydrides
  • Organic Building Blocks
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Anhydride Monomers
  • Monomers
  • Polymer Science
  • Carbonyl Compounds
Mol File:
5466-84-2.mol
More
Less

4-Nitrophthalic anhydride Chemical Properties

Melting point:
116-120 °C(lit.)
Boiling point:
197 °C / 8mmHg
Density 
1.6392 (rough estimate)
refractive index 
1.4700 (estimate)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Acetone (Slightly), Chloroform (Slightly), Methanol (Slightly)
form 
Solid
color 
Pale Beige
Water Solubility 
Hydrolysis
Sensitive 
Moisture Sensitive
BRN 
179682
CAS DataBase Reference
5466-84-2(CAS DataBase Reference)
NIST Chemistry Reference
4-Nitrophthalic anhydride(5466-84-2)
EPA Substance Registry System
5-Nitrophthalic anhydride (5466-84-2)
More
Less

Safety Information

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-20/22
Safety Statements 
26-36-36/37/39-22
WGK Germany 
3
RTECS 
TI3328000
10-21
TSCA 
Yes
HS Code 
29173990

MSDS

More
Less

4-Nitrophthalic anhydride Usage And Synthesis

Chemical Properties

off-white to light yellow-brown powder. Soluble in hot alcohol, hot acetic acid and acetone, insoluble in water.

Uses

4-Nitrophthalic anhydride is used an an intermediate for the synthesis of a benzimidazole PARP inhibitor I (succinate salt) (ABT-472).

Uses

5-Nitrophthalic Anhydride is used in the preparation of phthalic acids as well as compounds with anticonvulsant activities.

Preparation

4-Nitrophthalic anhydride is synthesized by hydrolysis of 4-nitrophthalimide and then dehydration. The 4-nitrophthalimide was added to the sodium hydroxide solution, heated and boiled for 15min. Adjust pH to 6-8 with nitric acid, and add nitric acid to boil for 5 min. Cooling, filtering, the filtrate was extracted with ether, the extract was dried and then the ether was evaporated, that is, 4-Nitrophthalic anhydride crystals were precipitated. Yield 95%.

General Description

Yellow powder.

Air & Water Reactions

Reacts with water. The organic acids produced by this reaction are significantly more soluble in water.

Reactivity Profile

4-Nitrophthalic anhydride reacts exothermically with water. The reactions are usually slow, but might become violent if local heating accelerates their rate. Acids accelerate the reaction with water. Incompatible with acids, strong oxidizing agents, alcohols, amines, and bases.

Fire Hazard

Flash point data for 4-Nitrophthalic anhydride are not available, however 4-Nitrophthalic anhydride is probably combustible.

Purification Methods

Distil the anhydride in a vacuum and/or recrystallise it from *C6H6 or Et2O/pet ether. Dry it in vacuo. It forms addition compounds with anthracene (m 118o), and phenanthrene (m 96o). [Beilstein 17 III/IV 6150, 17/11 V 267.]

Precautions

Moisture Sensitive. Store away from strong bases and oxidizing agents. Incompatible with water, bases, strong acids and oxidizing agents.

4-Nitrophthalic anhydride Preparation Products And Raw materials

Preparation Products

Raw materials

4-Nitrophthalic anhydrideSupplier

Jiangsu Lingyi Chemical Technology Co., Ltd. Gold
Tel
0523-87653988 15961022226
Email
214703666@qq.com
Energy Chemical Gold
Tel
021-021-58432009 400-005-6266
Email
sales8178@energy-chemical.com
Greenspring Biotechnology (Jiangsu) Co., Ltd. Gold
Tel
0523-87726088 13705266400
Email
sun1@sunmy.com
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Email
jkinfo@jkchemical.com
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Email
market03@meryer.com