(-)-PINORESINOL Chemical Properties

Melting point:

119-120 °C

Boiling point:

556.5±50.0 °C(Predicted)

Density 

1.287±0.06 g/cm3(Predicted)

solubility 

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

form 

Powder

pka

9.54±0.35(Predicted)

(-)-PINORESINOL Usage And Synthesis

Uses

(-)-Pinoresinol is a plant-derived tetrahydrofuran lignan that inhibits α-glucosidase and acts as a hypoglycemic agent. (-)-Pinoresinol has some anti-inflammatory effects and acts as a chemopreventive agent, inducing increased apoptosis and cell cycle G2/M arrest[1].

Definition

ChEBI: (-)-pinoresinol is an enantiomer of pinoresinol having (-)-1R,3aS,4R,6aS-configuration. It has a role as a plant metabolite.

target

TNF-α | COX | NF-kB | NOS | AP-1 | JNK | CDK | p21

References

[1] Lucia Fini, et al. Chemopreventive properties of pinoresinol-rich olive oil involve a selective activation of the ATM-p53 cascade in colon cancer cell lines. Carcinogenesis. 2008 Jan;29(1):139-46. DOI:10.1093/carcin/bgm255
[2] Alexandrine During, et al. Among plant lignans, pinoresinol has the strongest antiinflammatory properties in human intestinal Caco-2 cells. J Nutr. 2012 Oct;142(10):1798-805. DOI:10.3945/jn.112.162453

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