MORPHOLINOFORMAMIDINE HYDROBROMIDE Chemical Properties

Melting point:

155-165°C

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

Appearance

White to off-white Solid

Water Solubility 

Soluble in water.

Sensitive 

Hygroscopic

BRN 

7389038

Safety Information

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39

HS Code 

2934999090

MSDS

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MORPHOLINOFORMAMIDINE HYDROBROMIDE Usage And Synthesis

Uses

It is used as an active pharmaceutical intermediate.

Synthesis

Step 1: Thiourea (10.0g,0.13mol) was dissolved in anhydrous ethanol (30mL), ethidium bromide (15.8g, 0.14mol) was added, and the temperature was raised to 40?? until the reaction was completely soluble, and then stirred at 50?? overnight. Cooled to room temperature, evaporated the solvent under reduced pressure to obtain ethylisothiourea hydrobromide (crude 26g).

Step 2: Ethylisothiourea hydrobromide (24g of crude) and morpholine (13.6g, 0.156mol) were dissolved in water (100mL) and stirred at reflux at 110?? for 4 hours. The reaction solution was cooled to room temperature, concentrated under reduced pressure and brought to water twice with ethanol, then washed with methyl tert-butyl ether to give morpholinecarboximidamide hydrobromide (27 g, 96%). m/z=130 [M+1]+ MS (ESI+).

MORPHOLINOFORMAMIDINE HYDROBROMIDE(157415-17-3)Related Product Information

• MORPHOLINO(2-PIPERIDINYL)METHANONE HYDROCHLORIDE
• chloromethyl morpholine-4-carboxylate
• methyl morpholine-2-carboxylate hydrochloride
• MORPHOLIN-4-YL-ACETIC ACID
• Formamidinium Bromide
• Pyridinium tribromide
• CURING AGENT C
• MORPHOLIN-4-YL-PIPERAZIN-1-YL-METHANONE
• Morpholine-2-carbonitrile
• Hydrogen bromide
• MORPHOLINE-4-CARBOXAMIDINE HEMISULFATE
• MORPHOLINOFORMAMIDINE HYDROBROMIDE
• 1-(2-HYDROXYETHYL)GUANIDINE
• 4-(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)-2,6-DIMETHYLMORPHOLINE HYDROBROMIDE
• N-ETHYL-N-METHYLGUANIDINE
• N,N-DIMETHYL-GUANIDINE
• N,N-DIETHYL-GUANIDINE
• 2,6-DIMETHYLMORPHOLINOFORMAMIDINE HYDROBROMIDE