PHT-427 Chemical Properties

Melting point:

126-127 °C(Solv: hexane (110-54-3); ethyl acetate (141-78-6))

Boiling point:

535.0±43.0 °C(Predicted)

Density 

1.162

storage temp. 

+2C to +8C

solubility 

Chloroform, Methanol (Slightly)

form 

White solid

pka

6.03±0.40(Predicted)

color 

White to Off-White

PHT-427 Usage And Synthesis

Uses

PHT-427 is a dual Akt and PDPK1 inhibitor with Ki of 2.7 μM and 5.2 μM, respectively.

Uses

PHT-427 is a pleckstrin homology domain inhibitor to Akt and PKB Kinase (PDPK1). It can also be used for therapeutic use and biological study of mathematical modeling and parametric analysis of nanoparticle encapsulation and controlled release of a hydrophobic kinase inhibitor PHT-427.

Enzyme inhibitor

This orally bioavailable, dual Akt/PDPK1 inhibitor (F.Wt. = 409.61; CAS 1191951-57-1 and 1178893-77-0; Solubility (25°C): 80 mg/mL DMSO, <1 mg/mL Water), known systematically as 4-dodecyl-N-(1,3,4-thiadiazol-2- yl)benzenesulfonamide, targets Akt (also known as Protein Kinase B, or PKB) and 3-phosphoinositide-dependent protein kinase-1, with Ki of 2.7 μM and 5.2 μM, respectively. PHT-427 was designed to bind to the pleckstrin homology (PH) auto-inhibitory domains of the signal cascade protein kinase Akt.

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