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PHT-427

Basic information Safety Supplier Related

PHT-427 Basic information

Product Name:
PHT-427
Synonyms:
  • CS-303
  • Akt Inhibitor XIV - CAS 1191951-57-1 - Calbiochem
  • PHT-427
  • 4-Dodecyl-N-1,3,4-thiadiazol-2-ylbenzenesulfonamide
  • CS-0223
  • 4-Dodecyl-N-1,3,4-thiadiazol-2-ylbenzenesulfonamide PHT 427
  • PHT-427 4-Dodecyl-N-1,3,4-thiadiazol-2-ylbenzenesulfonamide
  • PHT-427;PHT 427
CAS:
1191951-57-1
MF:
C20H31N3O2S2
MW:
409.61
Product Categories:
  • PI3K/Akt/mTOR
  • Akt
  • Inhibitors
  • mTOR
  • PI3K
Mol File:
1191951-57-1.mol
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PHT-427 Chemical Properties

Melting point:
126-127 °C(Solv: hexane (110-54-3); ethyl acetate (141-78-6))
Boiling point:
535.0±43.0 °C(Predicted)
Density 
1.162
storage temp. 
+2C to +8C
solubility 
Chloroform, Methanol (Slightly)
form 
White solid
pka
6.03±0.40(Predicted)
color 
White to Off-White
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PHT-427 Usage And Synthesis

Uses

PHT-427 is a dual Akt and PDPK1 inhibitor with Ki of 2.7 μM and 5.2 μM, respectively.

Uses

PHT-427 is a pleckstrin homology domain inhibitor to Akt and PKB Kinase (PDPK1). It can also be used for therapeutic use and biological study of mathematical modeling and parametric analysis of nanoparticle encapsulation and controlled release of a hydrophobic kinase inhibitor PHT-427.

Enzyme inhibitor

This orally bioavailable, dual Akt/PDPK1 inhibitor (F.Wt. = 409.61; CAS 1191951-57-1 and 1178893-77-0; Solubility (25°C): 80 mg/mL DMSO, <1 mg/mL Water), known systematically as 4-dodecyl-N-(1,3,4-thiadiazol-2- yl)benzenesulfonamide, targets Akt (also known as Protein Kinase B, or PKB) and 3-phosphoinositide-dependent protein kinase-1, with Ki of 2.7 μM and 5.2 μM, respectively. PHT-427 was designed to bind to the pleckstrin homology (PH) auto-inhibitory domains of the signal cascade protein kinase Akt.

PHT-427Supplier

Shanghai Boyle Chemical Co., Ltd.
Tel
Email
sales@boylechem.com
Chembest Research Laboratories Limited
Tel
021-20908456
Email
sales@BioChemBest.com
Jinan Trio PharmaTech Co., Ltd.
Tel
+86 (531) 88811783
Email
sales@trio-pharmatech.com (International market)
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
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