ECDYSONE-2-ACETATE, BETA-(SH) Chemical Properties

Melting point:

218-220 °C

Boiling point:

707.3±60.0 °C(Predicted)

Density 

1.26±0.1 g/cm3(Predicted)

solubility 

DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 20 mg/ml; PBS (pH 7.2): 10 mg/ml

form 

A solid

pka

13.96±0.70(Predicted)

color 

White to off-white

ECDYSONE-2-ACETATE, BETA-(SH) Usage And Synthesis

Description

2-O-Acetyl-20-hydroxyecdysone is an ecdysone steroid hormone that has been found in plants and animals. It completely inhibits the growth of the bacteria S. aureus, E. coli, and P. vulgaris, as well as the fungi C. albicans, A. alternata, and F. solani when used at a concentration of 10 μg/ml. 2-O-Acetyl-20-hydroxyecdysone (50 μM) increases aggregation of amyloid-β (1-42) (Aβ42), increases fibril formation by 60%, and decreases oligomer levels in cell-free assays. It reduces Aβ42-induced cytotoxicity of SH-SY5Y cells when used at concentrations of 5 and 10 μM.

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