Strictosidinic acid
Strictosidinic acid Basic information
- Product Name:
- Strictosidinic acid
- Synonyms:
-
- Strictosidinic acid
- (2S,3R,4S)-3-Ethenyl-2-(beta-D-glucopyranosyloxy)-3,4-dihydro-4-[[(1S)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl]methyl]-2H-pyran-5-carboxylic acid
- 2H-Pyran-5-carboxylic acid, 3-ethenyl-2-(β-D-glucopyranosyloxy)-3,4-dihydro-4-[[(1S)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl]methyl]-, (2S,3R,4S)-
- CAS:
- 150148-81-5
- MF:
- C26H32N2O9
- MW:
- 516.54
- Mol File:
- 150148-81-5.mol
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Strictosidinic acid Chemical Properties
- Boiling point:
- 792.8±60.0 °C(Predicted)
- Density
- 1.50±0.1 g/cm3(Predicted)
- storage temp.
- 4°C, stored under nitrogen
- pka
- 4.67±0.70(Predicted)
- form
- Solid
- color
- Light yellow to yellow
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Strictosidinic acid Usage And Synthesis
Biological Activity
Strictosidinic acid, an glycosidic indole monoterpene alkaloid isolated from the leaves of Psychotria myriantha, inhibits the precursor enzymes of 5-HT biosynthesis and reduces 5-HT content. It has peripheral analgesic and antipyretic activity in mice.
in vivo
Strictosidinic acid (20 μg/μl; intra-hippocampal injection) causes a significance of 83.5% reduction in 5-HT levels. Strictosidinic acid (10 mg/kg; ip) causes a 63.4% reduction in 5- HT levels and a 67.4% reduction in DOPAC values in male Wistar rats, weighing 200-250 g.
target
| 5-HT Receptor
|
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