Benzofuran-2-carboxylic acid
Benzofuran-2-carboxylic acid Basic information
- Product Name:
- Benzofuran-2-carboxylic acid
- Synonyms:
-
- 4,5-BENZOFURAN-2-CARBOXYLIC ACID
- COUMARILIC ACID
- COUMARONE-2-CARBOXYLIC ACID
- BENZOFURAN-2-CARBOXYLIC ACID
- BENZO[B]FURAN-2-CARBOXYLIC ACID
- AURORA 2460
- RARECHEM AL BE 0556
- OTAVA-BB BB0125160292
- CAS:
- 496-41-3
- MF:
- C9H6O3
- MW:
- 162.14
- EINECS:
- 207-818-9
- Product Categories:
-
- Benzofurans
- Building Blocks
- Carboxylic Acids
- Furans, Benzofurans & Dihydrobenzofurans
- Chemical Synthesis
- Heterocyclic Building Blocks
- Furan&Benzofuran
- Carboxylic Acids
- Furans, Benzofurans & Dihydrobenzofurans
- Mol File:
- 496-41-3.mol
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Benzofuran-2-carboxylic acid Chemical Properties
- Melting point:
- 193-196 °C (lit.)
- Boiling point:
- 310-315°C
- Density
- 1.2599 (rough estimate)
- refractive index
- 1.5380 (estimate)
- Flash point:
- 310-315°C
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- soluble in Methanol,Ethanol,Acetone
- pka
- 3.12±0.30(Predicted)
- form
- Crystals or Powder
- color
- White to yellow
- Water Solubility
- partially soluble
- Merck
- 14,2561
- BRN
- 124204
- LogP
- 2.410
- CAS DataBase Reference
- 496-41-3(CAS DataBase Reference)
- NIST Chemistry Reference
- Benzofuran-2-carboxylic acid(496-41-3)
- EPA Substance Registry System
- 2-Benzofurancarboxylic acid (496-41-3)
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Safety Information
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-37/39
- WGK Germany
- 3
- RTECS
- DF6490000
- TSCA
- Yes
- HazardClass
- IRRITANT
- HS Code
- 29329985
- Toxicity
- mouse,LD50,intravenous,320mg/kg (320mg/kg),U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#02495,
MSDS
- Language:English Provider:ACROS
- Language:English Provider:SigmaAldrich
- Language:English Provider:ALFA
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Benzofuran-2-carboxylic acid Usage And Synthesis
Chemical Properties
white to light yellow crystal powde
Uses
Benzofuran-2-carboxylic acid was used in the synthesis of the oxymethyl-modified coumarinic acid-based cyclic DADLE (H-Tyr-D-Ala-Gly-Phe-D-Leu-OH) prodrug.
Synthesis Reference(s)
Journal of the American Chemical Society, 73, p. 872, 1951 DOI: 10.1021/ja01146a532
Organic Syntheses, Coll. Vol. 3, p. 209, 1955
Purification Methods
The acid crystallises from water. [Beilstein 18/6 V 419.]
Benzofuran-2-carboxylic acid Preparation Products And Raw materials
Raw materials
Benzofuran-2-carboxylic acidSupplier
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