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SAKURANETIN

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SAKURANETIN Basic information

Product Name:
SAKURANETIN
Synonyms:
  • SAKURANETIN
  • 5,4'-DIHYDROXY-7-O-METHOXYFLAVANONE
  • 4',5-DIHYDROXY-7-METHOXYFLAVANONE
  • SAKURANETIN(SH)
  • 5,4''-DIHYDROXY-7-METHOXYFLAVANONE MONOHYDRATE WITH HPLC
  • SAKURANETIN hplc
  • 5,4''-DIHYDROXY-7-METHOXYFLAVANONE
  • 5,4''-DIHYDROXY-7-METHOXYFLAVANONE WITH HPLC
CAS:
2957-21-3
MF:
C16H14O5
MW:
286.28
EINECS:
220-980-5
Product Categories:
  • Flavanones
Mol File:
2957-21-3.mol
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SAKURANETIN Chemical Properties

Melting point:
153-154°C
alpha 
D16 +8.0° (c = 7.92 in acetone); D12 +8.4° (c = 6.28 in methanol)
Boiling point:
555.9±50.0 °C(Predicted)
Density 
1.370±0.06 g/cm3(Predicted)
storage temp. 
Store at 2-8°C
solubility 
Chloroform (Slightly), Methanol (Slightly)
pka
7.42±0.40(Predicted)
form 
Solid
color 
White to Off-White
InChI
InChI=1S/C16H14O5/c1-20-11-6-12(18)16-13(19)8-14(21-15(16)7-11)9-2-4-10(17)5-3-9/h2-7,14,17-18H,8H2,1H3/t14-/m0/s1
InChIKey
DJOJDHGQRNZXQQ-AWEZNQCLSA-N
SMILES
[C@H]1(C2=CC=C(O)C=C2)OC2=CC(OC)=CC(O)=C2C(=O)C1
LogP
3.370 (est)
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Safety Information

Hazard Codes 
Xn
Risk Statements 
22
WGK Germany 
3
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SAKURANETIN Usage And Synthesis

Chemical Properties

Yellow crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Prunus serrulata, a plant of the genus Prunus in the Rosaceae family.

Uses

Sakuranetin is a flavanone phytoalexin reported to play an important role in disease resistance in rice plants. Antifungal and antimicrobial activity.

in vivo

Sakuranetin (20 mg/kg, intratracheal instillation, 10 μL) reduces inflammation, and reduces respiratory system elastance in an mice acute lung inflammation model induced by LPS[2].
Sakuranetin (20 mg/kg, intratracheal instillation) attenuates airway hyperresponsiveness and inflammation in Ovalbumin induced asthma murine model[5].

Animal Model:Acute lung inflammation mice model induced by LPS (5 mg/kg)[2]
Dosage:20 mg/kg
Administration:intratracheal instillation, 10 μL
Result:Reduced respiratory system elastance.
Decreased LPS-induced blood and pulmonary leukocytes.
Reduced proinflammatory cytokines, markers of M1- and M2-like macrophages, and activation of NF-κB in lung tissue.

SAKURANETINSupplier

ChengDu Yijierui Biotechnology CO., Ltd Gold
Tel
18224018291 18224018291
Email
yirui307@163.com
Zhengzhou Converging Chemical Co. LTD Gold
Tel
0371-53399770 18037166334
Email
2853031800@qq.com
Shanghai Boyi Pharmaceutical Technology Co., Ltd Gold
Tel
15901735131
Email
synthesis-d@foxmail.com
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006356688 18621169109
Email
market03@meryer.com
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Email
3bsc@sina.com
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