Aminodiphenylmethane hydrochloride Chemical Properties

Melting point:

293-295 °C(lit.)

Boiling point:

205-207 °C(Press: 4 Torr)

storage temp. 

Inert atmosphere,Room Temperature

form 

powder to crystal

color 

White to Almost white

Sensitive 

Hygroscopic

Merck 

14,1076

BRN 

3914818

CAS DataBase Reference

5267-34-5(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-37/39

WGK Germany 

3

HS Code 

29214990

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

Aminodiphenylmethane hydrochloride Usage And Synthesis

Chemical Properties

white to off-white crystalline powder

Uses

Benzhydrylamine Hydrochloride is used as molecular tools to block maturation of nuclear lamin A and decelerate cancer cell migration.

Synthesis

In the second step, benzophenone oxime (900 mg) was hydrogenated with a solution of concentrated hydrochloric acid (1.84 mL) in ethanol (50 mL) at atmospheric pressure in the presence of 10% Pd/C catalyst (100 mg). Upon completion of the reaction, the reaction mixture was filtered to remove the catalyst and the filtrate was subsequently concentrated. The concentrated residue was suspended in ethyl acetate and the suspension was filtered again to give the final diphenylmethylamine hydrochloride (2.17 g) as a white solid.

References

[1] Patent: EP2511283, 2012, A1. Location in patent: Page/Page column 91
[2] Patent: US2013/45942, 2013, A1. Location in patent: Paragraph 0379
[3] Patent: JP2015/172077, 2015, A. Location in patent: Paragraph 0187

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