CP-456773 sodium
CP-456773 sodium Basic information
- Product Name:
- CP-456773 sodium
- Synonyms:
-
- MCC950 sodium (CP-456773 sodium
- CP-456773 SODIUM; CRID3 SODIUM SALT; MCC-950 SODIUM; CP456773 SODIUM; CRID-3 SODIUM SALT
- N-[[(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-2-furansulfonamide sodium salt
- MCC950 (CP-456773) sodium
- CP-456773 sodium
- MCC950 sodium
- CP-456773 sodium salt
- N-[[(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-2-furansulfonamide monosodium salt
- CAS:
- 256373-96-3
- MF:
- C20H23N2NaO5S
- MW:
- 426.46179
- Product Categories:
-
- API
- Mol File:
- 256373-96-3.mol
CP-456773 sodium Chemical Properties
- storage temp.
- room temp
- solubility
- Soluble in DMSO:50.0(Max Conc. mg/mL);117.24(Max Conc. mM)
Water:30.0(Max Conc. mg/mL);70.35(Max Conc. mM) - form
- powder
- color
- white to beige
- Water Solubility
- water: 1mg/mL
DMSO: 50mg/mL - InChI
- InChI=1S/C20H24N2O5S.Na/c1-20(2,24)14-10-17(27-11-14)28(25,26)22-19(23)21-18-15-7-3-5-12(15)9-13-6-4-8-16(13)18;/h9-11,24H,3-8H2,1-2H3,(H2,21,22,23);/q;+1/p-1
- InChIKey
- LFQQNXFKPNZRFT-UHFFFAOYSA-M
- SMILES
- O=C(NC1C2CCCC=2C=C2CCCC=12)[N-]S(=O)(=O)C1OC=C(C(C)(O)C)C=1.[Na+]
CP-456773 sodium Usage And Synthesis
Uses
CP-456773 sodium salt has been used :
- In in vivo experiments to study the neuroprotective action of ketogenic diet.
- To study the effect of inhibition of NLRP3 (nod-like receptor protein 3) inflammasome activity on tumor progression in mouse models.
- To study the cholesterol crystal-mediated IL-1b (interleukin-1b) response in placental explants.
Biochem/physiol Actions
CP-456773 is known to inhibit the release of other proinflammatory cytokines such as IL-1α and IL-18. It is also referred to as MCC950.
in vivo
MCC950 reduces Interleukin-1p (IL-1β) production and attenuates the severity of experimental autoimmune encephalomyelitis (EAE), a disease model of multiple sclerosis. Pre-treatment with MCC950 reduces serum concentrations of IL-1β and IL-6 while it does not considerably decrease the amount of TNF-α. Treatment of mice with MCC950 delays the onset and reduced the severity of EAE. Intracellular cytokine staining and FACS analysis of brain mononuclear cells from mice sacrificed on day 22 shows modestly reduced frequencies of IL-17 and IFN-γ producing CD3+ T cells in MCC950 treated mice in comparison with PBS-treated mice. IFN-γ and particularly IL-17 producing cell numbers are also reduced in both the CD4+ and γδ+ sub-populations of CD3+ T cells[1].
IC 50
NLRP3
storage
+4°C
CP-456773 sodiumSupplier
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