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DIETHYL DIETHYLMALONATE

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DIETHYL DIETHYLMALONATE Basic information

Product Name:
DIETHYL DIETHYLMALONATE
Synonyms:
  • DIETHYLMALONIC ESTER
  • 2,2-diethyl-malonicaciddiethylester
  • Diethyl 2,2-diethylmalonate
  • Diethyldiethylpropanedioate
  • Diethylmalonate diethyl ester
  • Diethylpropanedioicaciddiethylester
  • diethyl-propanedioicacidiethylester
  • Malonic acid, diethyl-, diethyl ester
CAS:
77-25-8
MF:
C11H20O4
MW:
216.27
EINECS:
201-016-2
Product Categories:
  • API intermediates
  • Pharmaceutical Intermediates
Mol File:
77-25-8.mol
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DIETHYL DIETHYLMALONATE Chemical Properties

Boiling point:
228-230 °C (lit.)
Density 
0.99 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.423(lit.)
Flash point:
202 °F
storage temp. 
Sealed in dry,Room Temperature
solubility 
Chloroform, Methanol (Sparingly)
form 
Oil
color 
Clear Colourless
Specific Gravity
0.988 (20/4℃)
Merck 
14,3823
LogP
2.463 (est)
CAS DataBase Reference
77-25-8(CAS DataBase Reference)
EPA Substance Registry System
Propanedioic acid, diethyl-, diethyl ester (77-25-8)
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Safety Information

Safety Statements 
24/25
WGK Germany 
3
TSCA 
Yes
HS Code 
29171900

MSDS

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DIETHYL DIETHYLMALONATE Usage And Synthesis

Chemical Properties

clear colorless liquid. Quite powerful, fruity, Pear-like odor.

Uses

Diethyl Diethylmalonate is an intermediate in the synthesis of Barbital (B118500), a prototype of the barbiturate hypnotics.

Uses

manufacture of barbiturates.

Production Methods

This ester has been suggested for use in flavor compositions, but it is not sufficiently stable enough to become very popular. The ester has occasionally found use in perfume compositions, mainly as a modifier in fruity notes, winey top note bases, etc. Diethyl diethylmalonate is produced (several methods) e. g. by condensing Ethyl acetate with Ethyl oxalate, heat the resultant Oxaloacetic ester, and esterify the formed Diethyl malonic acid.

Synthesis Reference(s)

Journal of the American Chemical Society, 64, p. 578, 1942 DOI: 10.1021/ja01255a034

DIETHYL DIETHYLMALONATESupplier

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