DIETHYL DIETHYLMALONATE
DIETHYL DIETHYLMALONATE Basic information
- Product Name:
- DIETHYL DIETHYLMALONATE
- Synonyms:
-
- DIETHYLMALONIC ESTER
- 2,2-diethyl-malonicaciddiethylester
- Diethyl 2,2-diethylmalonate
- Diethyldiethylpropanedioate
- Diethylmalonate diethyl ester
- Diethylpropanedioicaciddiethylester
- diethyl-propanedioicacidiethylester
- Malonic acid, diethyl-, diethyl ester
- CAS:
- 77-25-8
- MF:
- C11H20O4
- MW:
- 216.27
- EINECS:
- 201-016-2
- Product Categories:
-
- API intermediates
- Pharmaceutical Intermediates
- Mol File:
- 77-25-8.mol
DIETHYL DIETHYLMALONATE Chemical Properties
- Boiling point:
- 228-230 °C (lit.)
- Density
- 0.99 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.423(lit.)
- Flash point:
- 202 °F
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Chloroform, Methanol (Sparingly)
- form
- Oil
- color
- Clear Colourless
- Specific Gravity
- 0.988 (20/4℃)
- Merck
- 14,3823
- LogP
- 2.463 (est)
- CAS DataBase Reference
- 77-25-8(CAS DataBase Reference)
- EPA Substance Registry System
- Propanedioic acid, diethyl-, diethyl ester (77-25-8)
Safety Information
- Safety Statements
- 24/25
- WGK Germany
- 3
- TSCA
- Yes
- HS Code
- 29171900
MSDS
- Language:English Provider:SigmaAldrich
- Language:English Provider:ACROS
- Language:English Provider:ALFA
DIETHYL DIETHYLMALONATE Usage And Synthesis
Chemical Properties
clear colorless liquid. Quite powerful, fruity, Pear-like odor.
Uses
Diethyl Diethylmalonate is an intermediate in the synthesis of Barbital (B118500), a prototype of the barbiturate hypnotics.
Uses
manufacture of barbiturates.
Production Methods
This ester has been suggested for use in flavor compositions, but it is not sufficiently stable enough to become very popular. The ester has occasionally found use in perfume compositions, mainly as a modifier in fruity notes, winey top note bases, etc. Diethyl diethylmalonate is produced (several methods) e. g. by condensing Ethyl acetate with Ethyl oxalate, heat the resultant Oxaloacetic ester, and esterify the formed Diethyl malonic acid.
Synthesis Reference(s)
Journal of the American Chemical Society, 64, p. 578, 1942 DOI: 10.1021/ja01255a034
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DIETHYL DIETHYLMALONATE(77-25-8)Related Product Information
- Diethyl dipropylmalonate
- Diethyl dibutylmalonate
- DIETHYL DIALLYLMALONATE
- Diethyl ethyl(isoamyl)malonate
- Diethyl ethyl(1-methylbutyl)malonate
- DIETHYL BIS(2-CYANOETHYL)MALONATE
- UV-144
- DIETHYL DIETHYLMALONATE
- DIETHYLMALONIC ACID
- ETHYLMALONIC ACID
- Diethyl ethylmalonate
- Malonic acid
- DIETHYL SEC-BUTYLETHYLMALONATE
- BUTYL TRIETHYL MALONATE
- DIETHYL 5-OXOCYCLOOCTANE-1,1-DICARBOXYLATE
- DIISOBUTYLMALONIC ACID DIETHYL ESTER
- DIETHYL ETHYL-N-AMYLMALONATE
- DIETHYL ETHYL N-PROPYL MALONATE