INCB28060 Dihydrochloride
INCB28060 Dihydrochloride Basic information
- Product Name:
- INCB28060 Dihydrochloride
- Synonyms:
-
- 2-Fluoro-N-methyl-4-[7-[(quinolin-6-yl)methyl]imidazo[1,2-b]-[1,2,4]triazin-2-yl]benzamide Dihydrochloride
- INCB28060 2HCl
- INCB28060 Dihydrochloride
- Capmatinib 2HCl
- INC-280 2HCl
- Capmatinib Dihydrochloride
- Benzamide, 2-fluoro-N-methyl-4-[7-(6-quinolinylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]-, hydrochloride (1:2)
- Capmatinib,Apoptosis,c-Met/HGFR,INC 280,H441,INCB28060,INC280,orally active,Capmatinib 2HCl,INCB-28060,SNU-5,INC-280,Inhibitor,S114,INCB 28060,inhibit,U-87MG,ATP competitive,Balb/c nu/nu mice
- CAS:
- 1197376-85-4
- MF:
- C23H18ClFN6O
- MW:
- 448.89
- EINECS:
- 695-736-8
- Product Categories:
-
- API
- API
- Mol File:
- 1197376-85-4.mol
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INCB28060 Dihydrochloride Usage And Synthesis
Description
INCB28060 Dihydrochloride is a novel, ATP-competitive inhibitor of c-MET kinase with an IC50 with 0.13 nM.
Uses
INCB28060 dihydrochloride exhibits picomolar enzymatic potency and is highly specific for c-MET with more than 10, 000-fold selectivity over a large panel of human kinases. This inhibitor potently blocks c-MET phosphorylation and activation of its key downstream effectors in c-MET-dependent tumor cell lines. As a result, INCB 28060 potently inhibits c-MET-dependent tumor cell proliferation and migration and effectively induces apoptosis in vitro.
INCB28060 DihydrochlorideSupplier
Anqing Benro pharmachem Technology Co.,Ltd. Gold
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Tianjin Zhongcheng Mingyuan Technology Co., Ltd. Gold
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Suzhou Ryan Pharmaceutical Technology Co., Ltd.
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Shanghai Arbor Chemical Co., Ltd.
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- 021-021-60451683 15021268886
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Sichuan Wei Keqi Biological Technology Co., Ltd.
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- 028-81700200 18116577057
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