NVS-PAK1-1
NVS-PAK1-1 Basic information
- Product Name:
- NVS-PAK1-1
- Synonyms:
-
- NVS-PAK1-1
- (3S)-3-(2-Chloro-5-(2,2-difluoroethyl)-8-fluoro-5H-dibenzo[b,e][1,4]diazepin-11-ylamino)-N-isopropylpyrrolidine-1-carboxamide
- NVS-PAK1-1;NVS-PAK11;NVS-PAK1 1
- 1-Pyrrolidinecarboxamide, 3-[[2-chloro-5-(2,2-difluoroethyl)-8-fluoro-5H-dibenzo[b,e][1,4]diazepin-11-yl]amino]-N-(1-methylethyl)-, (3S)-
- NVS-PAK1-1 >=98% (HPLC)
- NVS-PAK11Chemicalbook
- (S)-3-((2-Chloro-5-(2,2-difluoroethyl)-8-fluoro-5H-dibenzo[b,e][1,4]diazepin-11-yl)amino)-N-isopropylpyrrolidine-1-carboxamide
- Inhibitor,p21 activated kinases,NVS PAK1 1,inhibit,PAK,NVS-PAK-1-1,NVSPAK11
- CAS:
- 1783816-74-9
- MF:
- C23H25ClF3N5O
- MW:
- 479.93
- Product Categories:
-
- API
- Mol File:
- 1783816-74-9.mol
NVS-PAK1-1 Chemical Properties
- Boiling point:
- 697.8±55.0 °C(Predicted)
- Density
- 1.42±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMF: 50 mg/ml; DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml; DMSO: 50 mg/ml; Ethanol: 20 mg/ml
- form
- powder
- pka
- 14.02±0.40(Predicted)
- color
- white to beige
NVS-PAK1-1 Usage And Synthesis
Uses
NVS PAK1 1 is one of potent and selective allosteric PAK1 inhibitors.
Biochem/physiol Actions
NVS-PAK1-1 is a potent allosteric inhibitor of p21-activated kinase PAK1, a serine-threonine kinase that is upregulated in many cancers. NVS-PAK1-1 has an IC50 value of 5 nM for dephoshorylated PAK1 and 6 nM for phosphorylated PAK1 in an in vitro dephosphorylation assay. NVS-PAK1-1 showed good selectivity against 442 other kinases including PAK2. NVS-PAK1-1 has generally good physicochemical properties, but was metabolized by rat liver microsomes, so may not be useful for in vivo work. For full characterization details, please visit the NVS-PAK1-1 probe summary on the Structural Genomics Consortium (SGC) website.To learn about other SGC chemical probes for protein targets, visit sigma.com/sgc
storage
Store at -20°C
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