Basic information Safety Supplier Related

NVS-PAK1-1

Basic information Safety Supplier Related

NVS-PAK1-1 Basic information

Product Name:
NVS-PAK1-1
Synonyms:
  • NVS-PAK1-1
  • (3S)-3-(2-Chloro-5-(2,2-difluoroethyl)-8-fluoro-5H-dibenzo[b,e][1,4]diazepin-11-ylamino)-N-isopropylpyrrolidine-1-carboxamide
  • NVS-PAK1-1;NVS-PAK11;NVS-PAK1 1
  • 1-Pyrrolidinecarboxamide, 3-[[2-chloro-5-(2,2-difluoroethyl)-8-fluoro-5H-dibenzo[b,e][1,4]diazepin-11-yl]amino]-N-(1-methylethyl)-, (3S)-
  • NVS-PAK1-1 >=98% (HPLC)
  • NVS-PAK11Chemicalbook
  • (S)-3-((2-Chloro-5-(2,2-difluoroethyl)-8-fluoro-5H-dibenzo[b,e][1,4]diazepin-11-yl)amino)-N-isopropylpyrrolidine-1-carboxamide
  • Inhibitor,p21 activated kinases,NVS PAK1 1,inhibit,PAK,NVS-PAK-1-1,NVSPAK11
CAS:
1783816-74-9
MF:
C23H25ClF3N5O
MW:
479.93
Product Categories:
  • API
Mol File:
1783816-74-9.mol
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NVS-PAK1-1 Chemical Properties

Boiling point:
697.8±55.0 °C(Predicted)
Density 
1.42±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMF: 50 mg/ml; DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml; DMSO: 50 mg/ml; Ethanol: 20 mg/ml
form 
powder
pka
14.02±0.40(Predicted)
color 
white to beige
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NVS-PAK1-1 Usage And Synthesis

Uses

NVS PAK1 1 is one of potent and selective allosteric PAK1 inhibitors.

Biochem/physiol Actions

NVS-PAK1-1 is a potent allosteric inhibitor of p21-activated kinase PAK1, a serine-threonine kinase that is upregulated in many cancers. NVS-PAK1-1 has an IC50 value of 5 nM for dephoshorylated PAK1 and 6 nM for phosphorylated PAK1 in an in vitro dephosphorylation assay. NVS-PAK1-1 showed good selectivity against 442 other kinases including PAK2. NVS-PAK1-1 has generally good physicochemical properties, but was metabolized by rat liver microsomes, so may not be useful for in vivo work. For full characterization details, please visit the NVS-PAK1-1 probe summary on the Structural Genomics Consortium (SGC) website.To learn about other SGC chemical probes for protein targets, visit sigma.com/sgc

storage

Store at -20°C

NVS-PAK1-1Supplier

Chengdu Celes Technology Co., Ltd Gold
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Deyang Sino Biotech. Co., LTD Gold
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+86-19182167371 +86-19182167371
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Shanghai Lollane Biological Technology Co.,Ltd.
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Shanghaizehan biopharma technology co., Ltd.
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sales@zehanbiopharma.com