CATHARANTHINE TARTRATE
CATHARANTHINE TARTRATE Basic information
- Product Name:
- CATHARANTHINE TARTRATE
- Synonyms:
-
- CATHARANTHINE TARTRATE
- 7-ETHYL-9,10,12,13-TETRAHYDRO-6,9-METHANO-5H-PYRIDO[1',2':1,2]AZEPINO[4,5-B]INDOLE-6(6AH)-CARBOXYLIC ACID METHYL ESTER TARTRATE
- (2alpha,5beta,6alpha,18beta)-3,4-Didehydroibogamine-18-carboxylic acid methyl ester (2R,3R)-2,3-dihydroxybutanedioate
- Catharanthine hemitartrate
- (2α,5β,6α,18β)-3,4-Didehydro-ibogaMine-18-carboxylic Acid Methyl Ester Tartrate
- Bis[(5ξ,18ξ)-18-(methoxycarbonyl)-3,4-didehydroibogamin-6-ium] tartarate
- CATHARANTHINE TARTRATE USP/EP/BP
- Levofolene
- CAS:
- 4168-17-6
- MF:
- C25H30N2O8
- MW:
- 486.51
- Product Categories:
-
- chemical reagent
- pharmaceutical intermediate
- phytochemical
- reference standards from Chinese medicinal herbs (TCM).
- standardized herbal extract
- Anti-cancer & immunity
- Inhibitors
- Chiral Reagents
- Heterocycles
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Mol File:
- Mol File
CATHARANTHINE TARTRATE Chemical Properties
- Melting point:
- 145-1470C
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- DMSO (Slightly), Ethyl Acetate (Slightly, Heated), Methanol (Slightly, Heated)
- form
- White to off-white crystalline powder.
- color
- White to Pale Beige
- InChIKey
- JYBKPXVXYJDIFX-GYMDHWDQSA-N
- SMILES
- [C@]12(C(OC)=O)[C@]3(C(=C[C@]([H])(CN3CCC3C4=C(C=CC=C4)NC1=3)C2)CC)[H].C(O)(C(O)=O)C(O)C(O)=O
CATHARANTHINE TARTRATE Usage And Synthesis
Chemical Properties
Off-White to Pale Beige Solid
Uses
Precursor of Vinblastine-type alkaloids.
Synthesis
Using fresh whole Catharanthus roseus plant:
1) Soaking in NaCl solution, freeze-drying, and pulverizing.
2) Acidic extraction, basification, and counter-current extraction using a spray method with an extractant (n-bromopropane/ethanol).
3) Work-up of the organic phase and acidification.
4) Multiple extraction and pH adjustment steps yield crude catharanthine.
5) The crude base is salified with tartaric acid and recrystallized to obtain pure catharanthine tartrate.
in vivo
Catharanthine ((+)-3,4-Didehydrocoronaridine; 0.5-20 mg/kg; IV; single dose) Tartrate evokes dose-dependent reductions in both BP and HR[1].
Catharanthine (40 mg/kg; ip; single dose) Tartrate with acute administration induces similar antidepressant-like activity in male and female mice at 1 h and 24 h[1].
Catharanthine (20 mg/kg; ip; for 14 consecutive days) Tartrate increases swimming time and decreases immobility time at D7 or D14 in mice[1].
| Animal Model: | 13-week-old male SpragueDawley rats (300-350 g)[1] |
| Dosage: | 0.5-20 mg/kg |
| Administration: | IV; single dose |
| Result: | Evoked rapid, transient reductions in BP and HR (lasting ,2 minutes) at low doses (0.5–5 mg/kg), whereas at higher doses (10 and 20 mg/kg), the BP and HR reductions were sustained. |
IC 50
L-type calcium channel
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