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Uzarigenin

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Uzarigenin Basic information

Product Name:
Uzarigenin
Synonyms:
  • 3-beta,14-dihydroxy-5-alpha-card-20(22)-enolide
  • 3-beta-14-beta-5-allo-cardenolid
  • ODORIGENIN B
  • UZARIGENIN
  • 3β,14-Dihydroxy-5α-card-20(22)-enolide
  • Osin
  • Card-20(22)-enolide,3,14-dihydroxy-, (3b,5a)-
  • Card-20(22)-enolide, 3,14-dihydroxy-, (3β,5α)-
CAS:
466-09-1
MF:
C23H34O4
MW:
374.51
EINECS:
207-373-0
Product Categories:
  • Cardioglycosides & Glycosides
Mol File:
466-09-1.mol
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Uzarigenin Chemical Properties

Melting point:
240-256°
alpha 
D20 +10.5° (c = 1.056 in alc)
Boiling point:
549.3±50.0 °C(Predicted)
Density 
1.231±0.06 g/cm3(Predicted)
pka
14.93±0.70(Predicted)
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Safety Information

Toxicity
LDLo intravenous in cat: 1379ug/kg
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Uzarigenin Usage And Synthesis

Uses

Uzarigenin (NSC 119993; NSC 277290; Odorigeni) is a carnolide can be isolated from Pergularia tomentosa and exhibits antiproliferative activity. Uzarigenin resists the proliferation of PC3 cells, HeLa cells, Calu-1 cells, MCF-7 cells and U251MG cells, with IC50 values of 0.3 μM, 3.0 μM, 8.0 μM, 6.0 μM and 6.0 μM respectively[1].

References

[1] Hosseini SH, et al. Antiproliferative Cardenolides from the Aerial Parts of Pergularia tomentosa. J Nat Prod. 2019 Jan 25;82(1):74-79. DOI:10.1021/acs.jnatprod.8b00630

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