NADP sodium salt Chemical Properties

Melting point:

175-178 °C (dec.)(lit.)

storage temp. 

-20°C

solubility 

H₂O: 50 mg/mL

form 

powder

color 

off-white to yellow

PH

2.0-4.0

Water Solubility 

Soluble in water.

Merck 

14,6344

BRN 

4779954

InChI

InChI=1/C21H28N7O17P3.Na/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(44-46(33,34)35)14(30)11(43-21)6-41-48(38,39)45-47(36,37)40-5-10-13(29)15(31)20(42-10)27-3-1-2-9(4-27)18(23)32;/h1-4,7-8,10-11,13-16,20-21,29-31H,5-6H2,(H7-,22,23,24,25,32,33,34,35,36,37,38,39);/q;+1/p-1/t10-,11-,13-,14-,15-,16-,20-,21-;/s3

InChIKey

JNUMDLCHLVUHFS-QYZPTAICSA-M

SMILES

[C@H]1(O[C@H](COP([O-])(=O)OP([O-])(=O)OC[C@@H]2[C@@H](O)[C@@H](O)[C@H]([N+]3C=CC=C(C(=O)N)C=3)O2)[C@@H](O)[C@H]1OP(=O)(O)O)N1C=NC2C(N)=NC=NC1=2.[Na+] |&1:0,2,14,15,17,19,30,32,r|

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

36-36/37/38

Safety Statements 

22-24/25-37/39-36-26

WGK Germany 

3

RTECS 

UU3440000

HS Code 

29349990

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

NADP sodium salt Usage And Synthesis

Description

NADP sodium salt is a cofactor used in anabolic reactions, such as the Calvin cycle and lipid and nucleic acid syntheses, which require NADPH as a reducing agent ('hydrogen source').It is used by all forms of cellular life.

Chemical Properties

White to slightly yellowish powder

Uses

β-Nicotinamide adenine dinucleotide 2′-phosphate (NADP+) and β-Nicotinamide adenine dinucleotide 2′-phosphate, reduced (NADPH) comprise a coenzyme redox pair (NADP+:NADPH) involved in a wide range of enzyme catalyzed oxidation reduction reactions.
β-Nicotinamide Adenine Dinucleotide Phosphate Sodium Salt Hydrate is a substrate NADP which plays a role in a variety of metabolic processes.

Uses

NADP sodium salt acts as an electron acceptor used by cells. It is also useful in vitro to study NADP. Furthermore, it is used in a wide range of enzyme catalyzed oxidation reduction reactions. The combination of NADP+/NADPH is employed in a variety of antioxidation mechanisms, which protect against reactive oxidation species accumulation.

Biosynthesis

A process for preparing NADP sodium salt comprising performing phosphorylation using a polyphosphoric acid or a salt thereof and nicotinamide adenine dinucleotide (NAD+) as substrates in the presence of a polyphosphate-dependent NAD+ kinase from a Mycobacterium, wherein the reaction solution contains 0.1-15% by weight of the polyphosphoric acid or a salt thereof, and 5-150 mM of a divalent metal ion.

Biological Functions

NADP sodium salt is a coenzyme involved in cellular electron transfer reactions in biological metabolism, which is alternately oxidized (NADP+) and reduced (NADPH), and can maintain cellular redox homeostasis and regulate many biological events, including cellular metabolism. It plays a multifunctional role in regulating inflammation, redox homeostasis, and synthetic metabolism processes.

Biochem/physiol Actions

Electron acceptor

Mechanism of action

NADP sodium salt exerts its effect by competitively inhibiting nucleotide metabolism through the suppression of enzymes like nucleoside diphosphate kinase (NDPK) and adenosine kinase (ADK). Additionally, it serves as a substrate for enzymes like DNA polymerases and RNA polymerases, enabling the integration of NADP monosodium salt into nucleic acids during replication and transcription.

NADP sodium salt (1184-16-3)Related Product Information

• Nadph tetrasodium salt
• NADP, Disodium Salt
• NAD+
• Triphosphopyridine nucleotide
• Chlorotrimethylsilane
• Nicotinamide
• β-Nicotinamide Mononucleotide
• Adenosine triphosphate
• Adenosine-5'-diphosphate disodium salt
• Glutathione
• Superoxide dismutase
• Nicotinic acid
• NADH, disodium salt
• NADH Inhibitor
• Thionicotinamide adenine dinucleotide
• ATP disodium salt
• Adenosine-5'-diphosphate trilithium salt
• Riboflavin