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Thionicotinamide adenine dinucleotide

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Thionicotinamide adenine dinucleotide Basic information

Product Name:
Thionicotinamide adenine dinucleotide
Synonyms:
  • THIONICOTINAMIDE ADENINE DINUCLEOTIDE
  • THIONICOTINAMIDE-DPN
  • THIO-NAD
  • adenosine 5'-(trihydrogen diphosphate), 5'->5'-ester with 3-(aminothioxomethyl)-1-beta-D-ribofuranosylpyridinium--ate
  • Thionicotinamide-NAD
  • beta-Thionicotinamide adenine dinucleotide, oxidised form 92+%
  • 3-Thiocarbamoylpyridine adenine dinucleotide
  • 3-Thionicotinamide adenine dinucleotide
CAS:
4090-29-3
MF:
C21H27N7O13P2S
MW:
679.49
EINECS:
223-828-6
Product Categories:
  • nucleoside
Mol File:
4090-29-3.mol
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Thionicotinamide adenine dinucleotide Chemical Properties

storage temp. 
-20°C
form 
powder to crystal
color 
Light orange to Yellow to Green
InChIKey
DQRRIGAXTAXHLR-NNYOXOHSSA-N
SMILES
O[C@@H]1[C@@H]([C@@H](COP(O)(=O)OP([O-])(=O)OC[C@@H]2[C@H]([C@@H](O)[C@H]([N+]3=CC=CC(C(=S)N)=C3)O2)O)O[C@H]1N1C=NC2C(=NC=NC1=2)N)O |&1:1,2,3,15,16,17,19,32,r|
CAS DataBase Reference
4090-29-3
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Safety Information

Hazard Codes 
Xn
Risk Statements 
20/21/22-36/37/38
Safety Statements 
26-36
WGK Germany 
-
HS Code 
29349990

MSDS

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Thionicotinamide adenine dinucleotide Usage And Synthesis

Description

Thionicotinamide adenine dinucleotide is an analog of NAD. Use of Thio-NAD instead of NAD as a substrate for NAD(+)-consuming enzymes is more advantageous since the reduced form of Thio-NAD exhibits a substantial increase in absorbance at 405 nM, the most commonly available wavelength on microplate readers.

Chemical Properties

Light yellow powder

Uses

Thionicotinamide adenine dinucleotide has been used as a substrate analog in S-adenosyl-l-homocysteine (AdoHcy) hydrolases (SAHH) inhibition assay and in NAD+ glycohydrolase activity.

Application

Thionicotinamide adenine dinucleotide (thio-NAD) is a NAD derivative used in the determination of Carnitine by an enzymic cycling method with carnitine dehydrogenase.

Biochem/physiol Actions

Thionicotinamide adenine dinucleotide (sNAD) is an analog of coenzyme nicotinamide adenine dinucleotide (NAD) and NADH. sNAD is a potential inhibitor of NAD+ kinase. NAD+ kinase modulates NAD levels, contributing to cytotoxicity in cancer cells.

storage

Transport product sealed, dry, and protected from light at ambient temperature. Store product dry and protected from light. For long term storage keep below -20℃.

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