N-METHYLNICOTINAMIDE
N-METHYLNICOTINAMIDE Basic information
- Product Name:
- N-METHYLNICOTINAMIDE
- Synonyms:
-
- N'-METHYLNICOTINAMIDE
- N-METHYLNICOTINAMIDE
- METHYLNICOTINAMIDE, N-
- Methylnicotinamide
- 3-Pyridinecarboxamide, N-methyl-
- N-Methyl-3-pyridinecarboxamide.
- 3-Pyridinecarboxamide,N-methyl-(9CI)
- N-Methylnicotinamide, GC 98%
- CAS:
- 114-33-0
- MF:
- C7H8N2O
- MW:
- 136.15
- EINECS:
- 204-046-4
- Product Categories:
-
- AMIDE
- Mol File:
- 114-33-0.mol
N-METHYLNICOTINAMIDE Chemical Properties
- Melting point:
- 102-105 °C(lit.)
- Boiling point:
- 250.42°C (rough estimate)
- Density
- 1.1778 (rough estimate)
- refractive index
- 1.5769 (estimate)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 13.97±0.46(Predicted)
- color
- White to Off-White
- InChI
- InChI=1S/C7H8N2O/c1-8-7(10)6-3-2-4-9-5-6/h2-5H,1H3,(H,8,10)
- InChIKey
- ZYVXHFWBYUDDBM-UHFFFAOYSA-N
- SMILES
- C1=NC=CC=C1C(NC)=O
- CAS DataBase Reference
- 114-33-0(CAS DataBase Reference)
MSDS
- Language:English Provider:SigmaAldrich
- Language:English Provider:ACROS
N-METHYLNICOTINAMIDE Usage And Synthesis
Chemical Properties
white to light yellow-beige crystalline powder
Uses
N-Methylnicotinamide is a metabolite of Nicotinamide (N407750), which is a water-soluble vitamin B, incorporated within nicotinamide cofactors such as NADH and NADPH. N-Methylnicotinamide is commonly found in the human urine and is used as a biomarker to study diseases such as liver cirrhosis and type 2 diabetes.
Definition
ChEBI: A pyridinecarboxamide that is nicotinamide in which one of the amide hydrogens is substituted by a methyl group.
in vivo
N-Methylnicotinamide (3-30 mg/kg, i.v., 10 min before the induction of arterial thrombosis) decreases the arterial thrombus weight, collagen induced platelet aggregation and decreases PAI-1 antigen and activity in plasma without changing t-PA activity in 2K-1C hypertensive rats[1].
N-Methylnicotinamide (30-300 mg/kg, mixed in the diet, daily for 31 days) significantly increases the liver weight, the content of NAD and total nicotinamide in liver and the content of NAD in blood in rats[3].
| Animal Model: | 2K-1C hypertensive rats[1] |
| Dosage: | 3-30 mg/kg |
| Administration: | i.v., 10 min before the induction of arterial thrombosis |
| Result: | Resulted in a dose-dependent decrease of arterial thrombus weight, decreased PAI-1 antigen and activity in plasma in dose-dependent manner, whereas it did not change t-PA activity, decreased collagen induced platelet aggregation in dose-dependent manner. |
| Animal Model: | Weanling male rats[3] |
| Dosage: | 30-300 mg/kg |
| Administration: | mixed in the diet, daily for 31 days |
| Result: | Significantly increased the liver weight, statistically significantly the content of NAD and total nicotinamide in liver and the content of NAD in blood in rats. |
IC 50
Microbial Metabolite; Human Endogenous Metabolite
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N-METHYLNICOTINAMIDE(114-33-0)Related Product Information
- 6-METHYLPYRIDINE-3-CARBOXAMIDE (6-METHYLNICOTINAMIDE)
- Nicotinamide
- NADP, Disodium Salt
- Thionicotinamide adenine dinucleotide
- Ethionamide
- Nicotinamide riboside chloride
- NADH, disodium salt
- Nicotinamide-N-oxide
- N,N'-DIPYRIDIN-3-YLUREA
- N-ETHYLNICOTINAMIDE
- 5H-Pyrrolo[3,4-b]pyridine-5,7(6H)-dione
- nicopholine
- N-Nicotinoylglycine
- N-METHYLNICOTINAMIDE
- NICOTINANILIDE
- 3-Pyridinecarboxylic acid N-hydroxymethylamide
- N,N-DIETHYLNICOTINAMIDE
- 3,4-PYRIDINEDICARBOXIMIDE