Adenosine-5'-diphosphate disodium salt Chemical Properties

storage temp. 

-20°C

form 

Powder

color 

White

optical activity

[α]20/D 29.6±1°, c = 0.5% in 0.5 M Na2HPO4

Water Solubility 

Soluble in water.

Sensitive 

Hygroscopic

BRN 

3645656

InChIKey

AIZARHCNBKWDRW-KWIZKVQNSA-L

SMILES

[Na+].[Na+].C(OP(=O)(O)OP(O)(O)=O)[C@H]1O[C@@H](N2C3C(=C(N=CN=3)N)N=C2)[C@H]([O-])[C@@H]1[O-]

CAS DataBase Reference

16178-48-6(CAS DataBase Reference)

EPA Substance Registry System

Adenosine 5'-(trihydrogen diphosphate), disodium salt (16178-48-6)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

22-24/25-36-26

WGK Germany 

3

F 

10-21

TSCA 

Yes

HS Code 

29349990

MSDS

• Language:English Provider:5'-ADP-Na2
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

Adenosine-5'-diphosphate disodium salt Usage And Synthesis

Description

Adenosine-5'-diphosphate disodium salt is a sodium salt of adenosine 5'-diphosphate. Adenosine 5'-diphosphate disodium salt has been shown to inhibit the binding of serotonin (5-hydroxytryptamine) to 5-HT2 receptors, which are present in heart tissue.

Chemical Properties

White crystalline powder

Uses

Adenosine-5'-diphosphate disodium salt is an important raw material and intermediate used in organic synthesis, pharmaceuticals and agrochemicals.

Application

Adenosine-5'-diphosphate disodium salt is found in the extract of plants such as salvianolic acid and rhizoma gastrodiae, as well as in dinucleotide phosphate. This product has been shown to have cardioprotective effects against ischemia reperfusion injury in animal models. It also has congestive heart failure activity, which may be due to its ability to relax vascular smooth muscle and increase the diameter of lymphatic vessels.

Biochem/physiol Actions

Adenosine 5′-diphosphate (ADP) is an adenine nucleotide involved in energy storage and nucleic acid metabolism via its conversion into ATP by ATP synthases. ADP affects platelet activation through its interaction with purinergic receptors P2Y1 and P2Y12. Upon its conversion to adenosine by ecto-ADPases, platelet activation is inhibited via adenosine receptors.

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