Adenosine 5′-diphosphate sodium salt Chemical Properties

Melting point:

>174°C (dec.)

Boiling point:

877.7°

Flash point:

484.6°

storage temp. 

-20°C

solubility 

Aquoues Base (Slightly), Methanol (Slightly), Water (Slightly)

form 

Solid

color 

White to Off-White

biological source

bacterial

Water Solubility 

water: 50mg/mL

Stability:

Hygroscopic

InChIKey

NAZRYZKZIIRXMG-JHVGCDEENA-N

SMILES

O[C@@H]1[C@@H]([C@@H](COP(O)(=O)OP(O)(O)=O)O[C@H]1N1C=NC2C(=NC=NC1=2)N)O.[NaH] |&1:1,2,3,15,r|

CAS DataBase Reference

20398-34-9(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn

Risk Statements 

20/21/22-68/20/21/22

Safety Statements 

36/37-24/25

WGK Germany 

1

HS Code 

29349990

MSDS

• Language:English Provider:SigmaAldrich

Adenosine 5′-diphosphate sodium salt Usage And Synthesis

Description

Adenosine 5′-diphosphate sodium salt (ADP-NA) is an adenine nucleotide phosphorylated into ATP by ATPase. This phosphorylation is a crucial part of cellular homeostatis as it allows energy storage and is involved in nucleic acid metabolism. 

Uses

Adenosine 5'-diphosphate sodium salt  (ADP-NA) is a nucleoside diphosphate, which is the product of ATP dephosphorylation by ATPases. Adenosine 5'-diphosphate sodium salt induces human platelet aggregation and inhibits stimulated adenylate cyclase by an action at P2T-purinoceptors[1][2][3].

Biological Functions

Adenosine 5′-diphosphate sodium salt (ADP-NA) affects platelet activation through its interaction with ADP receptors P2Y1, P2Y12 and P2X1. Upon its conversion to adenosine by ecto-ADPases, platelet activation is inhibited via adenosine receptors.

IC 50

Human Endogenous Metabolite

References

[1] Arts IC, et al. Adenosine 5'-triphosphate (ATP) supplements are not orally bioavailable: a randomized, placebo-controlled cross-over trial in healthy humans. J Int Soc Sports Nutr. 2012 Apr 17;9(1):16. DOI:10.1186/1550-2783-9-16
[2] Noel J. Cusack, et al. Effects of phosphate-modified analogs of adenosine 5′-diphosphate and adenosine 5′‐triphosphate at P2T-purinoceptors mediating human platelet activation by ADP. April 1996.
[3] Adenosine-5'-diphosphate

Adenosine 5′-diphosphate sodium salt(20398-34-9)Related Product Information

• Adenosine-5'-diphosphate disodium salt
• ADENOSINE 5'-TRIPHOSPHATE DISODIUM SAL&
• Inosine-5'-diphosphoric acid disodium salt
• Adenosine 5'-monophosphate monohydrate
• ATP disodium salt
• Phosphoric acid
• ADP
• Adenosine 5'-monophosphate disodium salt
• ADENOSINE 5'-DIPHOSPHATE DI(MONOCYCLOHEXYLAMMONIUM) SALT
• ADENOSINE-5'-MONOPHOSPHATE DISODIUM SALT
• Vidarabine monophosphate
• Cytidine 5'-diphosphate trisodium salt
• Adenosine5'-(tetrahydrogen triphosphate), disodiuM salt, trihydrate (9CI)
• 2'-BROMO-ADENOSINE-5'-DIPHOSPHATE, SODIUM SALT
• 8-BROMO-ADENOSINE-5'-DIPHOSPHATE, SODIUM SALT
• 2'-IODO-ADENOSINE-5'-DIPHOSPHATE, SODIUM SALT
• 8-IODO-ADENOSINE-5'-DIPHOSPHATE, SODIUM SALT
• 2'/3'-O-(2-AMINOETHYL-CARBAMOYL)-ADENOSINE-5'-DIPHOSPHATE, SODIUM SALT