Naftopidil dihydrochloride Chemical Properties

Melting point:

127 °C

Boiling point:

517.2°C (rough estimate)

Density 

1.1592 (rough estimate)

refractive index 

1.6300 (estimate)

storage temp. 

Sealed in dry,Room Temperature

solubility 

methanol: >10 mg/mL

pka

14.01±0.20(Predicted)

form 

solid

color 

white

Merck 

14,6356

CAS DataBase Reference

57149-07-2(CAS DataBase Reference)

Safety Information

RIDADR 

3077

WGK Germany 

3

RTECS 

TL9336500

HS Code 

29335990

Toxicity

LD50 in mice, rats (g/kg): 1.3, 6.4 orally (Himmel)

MSDS

• Language:English Provider:Naftopidil dihydrochloride

Naftopidil dihydrochloride Usage And Synthesis

Description

Naftopidil was launched in Japan for the treatment of dysuria associated with benign prostatic hypertrophy (BPH). It can be prepared by a two step route starting with α-naphthol. Naftopidil is a potent postsynaptic-selective alpha-l-antagonist with a slightly higher affinity for the human prostatic than for the aortic alpha-adrenoceptor. It also shows a 5-HT1A agonistic effect, as well as a weak calcium antagonistic activity, but no alpha-2 or beta-adrenoreceptor affinity. In experiments with rats or rabbits, Naftopidil was shown to be more potent and selective for the urodynamic effect than the hypotensive effect. Aromatic or aliphatic hydroxylation are the major routes of metabolism, producing metabolites with a profile similar to the parent compound.

Chemical Properties

Off-White Solid

Originator

Boehringer Mannheim (Germany)

Uses

Naftopidil is an α-1-adrenergic receptor antagonist. Naftopidil is used as an antihypertensive.

Uses

A α-1-Adrenergic receptor antagonist, antihypertensive.

Uses

antihypertensive, alpha-blocker, 5HT1a agonist

Definition

ChEBI: Naftopidil is a member of piperazines.

brand name

Avishot;Flivas

Biological Activity

An α 1 -adrenoceptor antagonist with only weak antagonism at post-junctional α 2 receptors; a potent, persistent antihypertensive and vasodilator.

Naftopidil dihydrochloride(57149-07-2)Related Product Information

• Anisole
• (Trifluoromethoxy)benzene
• Piperazine
• Methyl acetate
• Diphenolic acid
• 1-AdaMantanethylaMine
• Methyl acrylate
• Thiophanate-methyl
• DL-α-Tocopherol
• Bensulfuron methyl
• p-Anisaldehyde
• N-Aminoethylpiperazine
• Diphenyldimethoxysilane
• p-Anisidine
• Methylparaben
• 2-Ethylhexyl ferulate
• Piperacillin
• Kresoxim-methyl