ChemicalBook > CAS DataBase List > Naftopidil dihydrochloride
Naftopidil dihydrochloride
- Product Name
- Naftopidil dihydrochloride
- CAS No.
- 57149-07-2
- Chemical Name
- Naftopidil dihydrochloride
- Synonyms
- kt-611;Flivas;Avishot;BM-15275;Naftopil;Naftopiil;NafTopIDi1;NAFTOPIDIL;Nafitopidil;Naftopidil>
- CBNumber
- CB6356910
- Molecular Formula
- C24H28N2O3
- Formula Weight
- 392.49
- MOL File
- 57149-07-2.mol
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Naftopidil dihydrochloride Property
- Melting point:
- 127 °C
- Boiling point:
- 517.2°C (rough estimate)
- Density
- 1.1592 (rough estimate)
- refractive index
- 1.6300 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- methanol: >10 mg/mL
- pka
- 14.01±0.20(Predicted)
- form
- solid
- color
- white
- Merck
- 14,6356
- CAS DataBase Reference
- 57149-07-2(CAS DataBase Reference)
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Safety
- RIDADR
- 3077
- WGK Germany
- 3
- RTECS
- TL9336500
- HS Code
- 29335990
- Toxicity
- LD50 in mice, rats (g/kg): 1.3, 6.4 orally (Himmel)
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H361Suspected of damaging fertility or the unborn child
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P281Use personal protective equipment as required.
P308+P313IF exposed or concerned: Get medical advice/attention.
P405Store locked up.
P501Dispose of contents/container to..…
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- N158
- Product name
- Naftopidil hydrochloride hydrate
- Purity
- solid
- Packaging
- 25mg
- Price
- $240
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- N158
- Product name
- Naftopidil hydrochloride hydrate
- Purity
- solid
- Packaging
- 100mg
- Price
- $774
- Updated
- 2023/01/07
TCI Chemical
- Product number
- N0832
- Product name
- Naftopidil
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $50
- Updated
- 2024/03/01
TRC
- Product number
- N213501
- Product name
- Naftopidil
- Packaging
- 25mg
- Price
- $80
- Updated
- 2021/12/16
Usbiological
- Product number
- 285070
- Product name
- Naftopidil
- Packaging
- 1g
- Price
- $345
- Updated
- 2021/12/16
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Naftopidil dihydrochloride Chemical Properties,Usage,Production
Description
Naftopidil was launched in Japan for the treatment of dysuria associated with benign prostatic hypertrophy (BPH). It can be prepared by a two step route starting with α-naphthol. Naftopidil is a potent postsynaptic-selective alpha-l-antagonist with a slightly higher affinity for the human prostatic than for the aortic alpha-adrenoceptor. It also shows a 5-HT1A agonistic effect, as well as a weak calcium antagonistic activity, but no alpha-2 or beta-adrenoreceptor affinity. In experiments with rats or rabbits, Naftopidil was shown to be more potent and selective for the urodynamic effect than the hypotensive effect. Aromatic or aliphatic hydroxylation are the major routes of metabolism, producing metabolites with a profile similar to the parent compound.
Chemical Properties
Off-White Solid
Originator
Boehringer Mannheim (Germany)
Uses
Naftopidil is an α-1-adrenergic receptor antagonist. Naftopidil is used as an antihypertensive.
Uses
A α-1-Adrenergic receptor antagonist, antihypertensive.
Uses
antihypertensive, alpha-blocker, 5HT1a agonist
Definition
ChEBI: Naftopidil is a member of piperazines.
brand name
Avishot;Flivas
Biological Activity
An α 1 -adrenoceptor antagonist with only weak antagonism at post-junctional α 2 receptors; a potent, persistent antihypertensive and vasodilator.
Naftopidil dihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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Naftopidil dihydrochloride Suppliers
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View Lastest Price from Naftopidil dihydrochloride manufacturers
WUHAN FORTUNA CHEMICAL CO., LTD
- Product
- Naftopidil dihydrochloride 57149-07-2
- Price
- US $0.00-0.00/g
- Min. Order
- 100g
- Purity
- 99.0%
- Supply Ability
- 50kg/month
- Release date
- 2021-07-26
Hebei Mingeng Biotechnology Co., Ltd
- Product
- Naftopidil 57149-07-2
- Price
- US $120.00/ASSAYS
- Min. Order
- 10g
- Purity
- >99%
- Supply Ability
- 500kg/month
- Release date
- 2021-11-18
Hebei Guanlang Biotechnology Co,.LTD
- Product
- Naftopidil 57149-07-2
- Price
- US $19.10/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 ton
- Release date
- 2021-07-19
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