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Naftopidil dihydrochloride

Product Name
Naftopidil dihydrochloride
CAS No.
57149-07-2
Chemical Name
Naftopidil dihydrochloride
Synonyms
kt-611;Flivas;Avishot;BM-15275;Naftopil;Naftopiil;NafTopIDi1;NAFTOPIDIL;Nafitopidil;Naftopidil>
CBNumber
CB6356910
Molecular Formula
C24H28N2O3
Formula Weight
392.49
MOL File
57149-07-2.mol
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Naftopidil dihydrochloride Property

Melting point:
127 °C
Boiling point:
517.2°C (rough estimate)
Density 
1.1592 (rough estimate)
refractive index 
1.6300 (estimate)
storage temp. 
Sealed in dry,Room Temperature
solubility 
methanol: >10 mg/mL
pka
14.01±0.20(Predicted)
form 
solid
color 
white
Merck 
14,6356
CAS DataBase Reference
57149-07-2(CAS DataBase Reference)
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Safety

RIDADR 
3077
WGK Germany 
3
RTECS 
TL9336500
HS Code 
29335990
Toxicity
LD50 in mice, rats (g/kg): 1.3, 6.4 orally (Himmel)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P281Use personal protective equipment as required.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
N158
Product name
Naftopidil hydrochloride hydrate
Purity
solid
Packaging
25mg
Price
$240
Updated
2024/03/01
Sigma-Aldrich
Product number
N158
Product name
Naftopidil hydrochloride hydrate
Purity
solid
Packaging
100mg
Price
$774
Updated
2023/01/07
TCI Chemical
Product number
N0832
Product name
Naftopidil
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$50
Updated
2024/03/01
TRC
Product number
N213501
Product name
Naftopidil
Packaging
25mg
Price
$80
Updated
2021/12/16
Usbiological
Product number
285070
Product name
Naftopidil
Packaging
1g
Price
$345
Updated
2021/12/16
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Naftopidil dihydrochloride Chemical Properties,Usage,Production

Description

Naftopidil was launched in Japan for the treatment of dysuria associated with benign prostatic hypertrophy (BPH). It can be prepared by a two step route starting with α-naphthol. Naftopidil is a potent postsynaptic-selective alpha-l-antagonist with a slightly higher affinity for the human prostatic than for the aortic alpha-adrenoceptor. It also shows a 5-HT1A agonistic effect, as well as a weak calcium antagonistic activity, but no alpha-2 or beta-adrenoreceptor affinity. In experiments with rats or rabbits, Naftopidil was shown to be more potent and selective for the urodynamic effect than the hypotensive effect. Aromatic or aliphatic hydroxylation are the major routes of metabolism, producing metabolites with a profile similar to the parent compound.

Chemical Properties

Off-White Solid

Originator

Boehringer Mannheim (Germany)

Uses

Naftopidil is an α-1-adrenergic receptor antagonist. Naftopidil is used as an antihypertensive.

Uses

A α-1-Adrenergic receptor antagonist, antihypertensive.

Uses

antihypertensive, alpha-blocker, 5HT1a agonist

Definition

ChEBI: Naftopidil is a member of piperazines.

brand name

Avishot;Flivas

Biological Activity

An α 1 -adrenoceptor antagonist with only weak antagonism at post-junctional α 2 receptors; a potent, persistent antihypertensive and vasodilator.

Naftopidil dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Naftopidil dihydrochloride Suppliers

Americas 1 Belgium 1 Brazil 1 Canada 3 China 257 Europe 3 Germany 3 India 21 Italy 2 Japan 6 Poland 1 South Korea 2 Switzerland 3 United Arab Emirates 1 United Kingdom 11 United States 37 Global 353
DISCOVERY Importacao e Exportacao Ltda
Tel
--
Fax
--
Email
discovery@discoverychem.com.br
Country
Brazil
ProdList
390
Advantage
58
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View Lastest Price from Naftopidil dihydrochloride manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Naftopidil dihydrochloride 57149-07-2
Price
US $0.00-0.00/g
Min. Order
100g
Purity
99.0%
Supply Ability
50kg/month
Release date
2021-07-26
Hebei Chuanghai Biotechnology Co,.LTD
Product
Naftopidil 57149-07-2
Price
US $19.10/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 ton
Release date
2024-08-09
Hebei Mingeng Biotechnology Co., Ltd
Product
Naftopidil 57149-07-2
Price
US $120.00/ASSAYS
Min. Order
10g
Purity
>99%
Supply Ability
500kg/month
Release date
2021-11-18

57149-07-2, Naftopidil dihydrochlorideRelated Search:

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  • C24H28N2O3
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  • AVISHOT