Naftopidil dihydrochloride

ChemicalBook > CAS DataBase List > Naftopidil dihydrochloride

Naftopidil dihydrochloride

Product Name: Naftopidil dihydrochloride
CAS No.: 57149-07-2
Chemical Name: Naftopidil dihydrochloride
Synonyms: kt-611;Flivas;Avishot;BM-15275;Naftopil;Naftopiil;NafTopIDi1;NAFTOPIDIL;Nafitopidil;Naftopidil>
CBNumber: CB6356910
Molecular Formula: C24H28N2O3
Formula Weight: 392.49
MOL File: 57149-07-2.mol

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Naftopidil dihydrochloride Property

Melting point:: 127 °C
Boiling point:: 517.2°C (rough estimate)
Density: 1.1592 (rough estimate)
refractive index: 1.6300 (estimate)
storage temp.: Sealed in dry,Room Temperature
solubility: methanol: >10 mg/mL
pka: 14.01±0.20(Predicted)
form: solid
color: white
Merck: 14,6356
CAS DataBase Reference: 57149-07-2(CAS DataBase Reference)

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Safety

RIDADR: 3077
WGK Germany: 3
RTECS: TL9336500
HS Code: 29335990
Toxicity: LD50 in mice, rats (g/kg): 1.3, 6.4 orally (Himmel)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P281Use personal protective equipment as required.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: N158
Product name: Naftopidil hydrochloride hydrate
Purity: solid
Packaging: 25mg
Price: $240
Updated: 2024/03/01

Sigma-Aldrich

Product number: N158
Product name: Naftopidil hydrochloride hydrate
Purity: solid
Packaging: 100mg
Price: $774
Updated: 2023/01/07

TCI Chemical

Product number: N0832
Product name: Naftopidil
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $50
Updated: 2024/03/01

TRC

Product number: N213501
Product name: Naftopidil
Packaging: 25mg
Price: $80
Updated: 2021/12/16

Usbiological

Product number: 285070
Product name: Naftopidil
Packaging: 1g
Price: $345
Updated: 2021/12/16

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Naftopidil dihydrochloride Chemical Properties,Usage,Production

Description

Naftopidil was launched in Japan for the treatment of dysuria associated with benign prostatic hypertrophy (BPH). It can be prepared by a two step route starting with α-naphthol. Naftopidil is a potent postsynaptic-selective alpha-l-antagonist with a slightly higher affinity for the human prostatic than for the aortic alpha-adrenoceptor. It also shows a 5-HT1A agonistic effect, as well as a weak calcium antagonistic activity, but no alpha-2 or beta-adrenoreceptor affinity. In experiments with rats or rabbits, Naftopidil was shown to be more potent and selective for the urodynamic effect than the hypotensive effect. Aromatic or aliphatic hydroxylation are the major routes of metabolism, producing metabolites with a profile similar to the parent compound.

Chemical Properties

Off-White Solid

Originator

Boehringer Mannheim (Germany)

Uses

Naftopidil is an α-1-adrenergic receptor antagonist. Naftopidil is used as an antihypertensive.

Uses

A α-1-Adrenergic receptor antagonist, antihypertensive.

Uses

antihypertensive, alpha-blocker, 5HT1a agonist

Definition

ChEBI: Naftopidil is a member of piperazines.

brand name

Avishot;Flivas

Biological Activity

An α 1 -adrenoceptor antagonist with only weak antagonism at post-junctional α 2 receptors; a potent, persistent antihypertensive and vasodilator.

Naftopidil dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Naftopidil dihydrochloride Suppliers

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View Lastest Price from Naftopidil dihydrochloride manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Naftopidil dihydrochloride 57149-07-2
Price: US $0.00-0.00/g
Min. Order: 100g
Purity: 99.0%
Supply Ability: 50kg/month
Release date: 2021-07-26

Hebei Mingeng Biotechnology Co., Ltd

Product: Naftopidil 57149-07-2
Price: US $120.00/ASSAYS
Min. Order: 10g
Purity: >99%
Supply Ability: 500kg/month
Release date: 2021-11-18

Hebei Guanlang Biotechnology Co,.LTD

Product: Naftopidil 57149-07-2
Price: US $19.10/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 ton
Release date: 2021-07-19

57149-07-2, Naftopidil dihydrochlorideRelated Search:

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NAFTOPIDIL

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NafTopIDi1

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Naftopidil dihydrochloride

Avishot

Flivas

Naftopidil DihydrochlorideSee: N213501

rac-4-(2-Methoxyphenyl)-a-[(1-naphthalenyloxy)methyl]-1-piperazineethanol Dihydrochloride

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3-[4-(2-Methoxyphenyl)piperazinyl]-1-naphthyloxypropan-2-ol

Naftopidil and intermediates

1-[4-(2-Methoxyphenyl)piperazin-1-yl]-3-naphthalen-1-yloxy-propan-2-ol

(R)-1-(1-Naphtyloxy)-3-[4-(2-methoxyphenyl)piperazino]-2-propanol

[R,(+)]-1-[4-(2-Methoxyphenyl)-1-piperazinyl]-3-(1-naphtyloxy)-2-propanol

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[S,(-)]-1-[4-(2-Methoxyphenyl)-1-piperazinyl]-3-(1-naphtyloxy)-2-propanol

1-[4-(2-Methoxyphenyl)-1-piperazinyl]-3-(1-naphtyloxy)-2-propanol

4-(2-Methoxyphenyl)-α-[(naphthalen-1-yloxy)methyl]piperazine-1-ethanol

4-(2-Methoxyphenyl)-α-[(1-naphthalenyloxy)methyl]-1-piperazineethanol hydrochloride hydrate

4-(2-Methoxyphenyl)-α-[(1-naphthalenyloxy)methyl]-1-piperazineethanolhydrochloride

rac-4-(2-Methoxyphenyl)-α-[(1-naphthalenyloxy)methyl]-1-piperazineethanol Dihydrochloride

4-(2-Methoxyphenyl)-α-[(1-naphthalenyloxy)methyl]-1-piperazineethanol,

KT-611, 4-(2-Methoxyphenyl)-α-[(1-naphthalenyloxy)methyl]-1-piperazineethanol hydrate hydrochloride

Naftopidil hydrate hydrochloride

BM-15275

Naftopidil(Flivas)

CAS No:57149-07-2 1-Piperazineethanol,4-(2-Methoxyphenyl)-a-[(1-naphthalenyloxy)Methyl]-

Naftopiil

Naftopil

Naftopidil hydrochloride hydrate

1-[4-(2-Methoxyphenyl)piperazin-1-yl]-3-(1-naphthyloxy)propan-2-ol

Naftopidil, 98%, a selective α1-adrenergic receptor antagonist

Naftopidil&gt

Naftopidil Naftopidil

Naftopidil,>98%

1-Piperazineethanol, 4-(2-methoxyphenyl)-α-[(1-naphthalenyloxy)methyl]-

4-(2-Methoxyphenyl)-alpha-[(1-naphthalenyloxy)methyl]-1-piperazineethanol

Naftopidil hydrochlo

Naftopidil D7Q: What is Naftopidil D7 Q: What is the CAS Number of Naftopidil D7 Q: What is the storage condition of Naftopidil D7 Q: What are the applications of Naftopidil D7

NaftopidilQ: What is Naftopidil Q: What is the CAS Number of Naftopidil Q: What is the storage condition of Naftopidil Q: What are the applications of Naftopidil

1-Piperazineethanol, 4-(2-methoxyphenyl)-α-[(1-naphthalenyloxy)methyl]-

Naftopidil, ≥ 98.0%

57149-07-2

7149-07-2

C24H28N2O3

C24H30Cl2N2O3

C24H28N2O3HCl

AVISHOT