10-Gingerol Chemical Properties

Melting point:

56-58 °C

Boiling point:

499.7±35.0 °C(Predicted)

Density 

1.037±0.06 g/cm3(Predicted)

Flash point:

166℃

storage temp. 

2-8°C

solubility 

methanol: soluble5mg/mL, clear, colorless

pka

10.02±0.20(Predicted)

form 

Solid

color 

Yellow

Water Solubility 

practically insoluble in water

InChI

InChI=1S/C21H34O4/c1-3-4-5-6-7-8-9-10-18(22)16-19(23)13-11-17-12-14-20(24)21(15-17)25-2/h12,14-15,18,22,24H,3-11,13,16H2,1-2H3/t18-/m0/s1

InChIKey

AIULWNKTYPZYAN-SFHVURJKSA-N

SMILES

C(C1=CC=C(O)C(OC)=C1)CC(=O)C[C@@H](O)CCCCCCCCC

LogP

4.900 (est)

Safety Information

Risk Statements 

53

Safety Statements 

24/25

WGK Germany 

3

HS Code 

29145019

10-Gingerol Usage And Synthesis

Description

10-Gingerol is a phenol that has been found in Z. officinale and has diverse biological activities. It scavenges DPPH , superoxide, and hydroxyl radicals in cell-free assays (IC₅₀s = 10.47, 1.68, and 1.35 μM, respectively) and inhibits oxidative burst induced by N-formyl-Met-Leu-Phe (fMLP; ) in isolated human polymorphonuclear (PMN) neutrophils when used at a concentration of 6 μM. 10-Gingerol inhibits NETosis and the production of reactive oxygen species (ROS) induced by LPS or lupus-relevant stimuli, including ribonucleoprotein-containing immune complexes and anti-phospholipid antibodies, in isolated human neutrophils. It is active against M. avium and M. tuberculosis (MICs = 25 and 50 μg/ml, respectively). 10-Gingerol (200 μM) is also cytotoxic to human MDA-MB-231 and MDA-MB-468 and murine 4T1 and EO771 mammary carcinoma cells.

Uses

(+)-(S)-[10]-Gingerol has been observed to exhibit anti-oxidant behaviour towards lipids and is effective in suppressing obesity and adipose tissue inflammation.

Definition

ChEBI: (10)-Gingerol is a beta-hydroxy ketone, a member of phenols and a monomethoxybenzene.

Biochem/physiol Actions

[10]-Gingerol is a bioactive compound found in ginger (Zingiber officinale) with anti-inflammatory and antioxidant activity.

10-Gingerol(23513-15-7)Related Product Information

• DIPHENYLCYCLOPROPENONE
• Diphenylsilanediol
• 4-Methoxyphenylacetone
• 4'-Hydroxyacetophenone
• Benzoylcyclohexane
• Phenylfluorone
• 6-Gingerol
• Diacetone Alcohol
• CHLOROPHOSPHONAZO III
• 2'-Hydroxyacetophenone
• 8-GINGEROL
• 4-tetradecylphenol
• Tetradecane
• Vanillylacetone
• 3-TETRADECANONE
• gingerol
• 6-GINGEROL,(+/-)
• 8-PARADOL