2,5-Bis(2,2,2-trifluoroethoxy)benzoic acid Chemical Properties

Melting point:

119-121°C

Boiling point:

320.9±42.0 °C(Predicted)

Density 

1.474±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

solubility 

DMSO (Slightly), Methanol (Slightly, Heated)

pka

3.06±0.36(Predicted)

form 

Solid

color 

Off-white

InChI

InChI=1S/C11H8F6O4/c12-10(13,14)4-20-6-1-2-8(7(3-6)9(18)19)21-5-11(15,16)17/h1-3H,4-5H2,(H,18,19)

InChIKey

YPGYLCZBZKRYQJ-UHFFFAOYSA-N

SMILES

C(O)(=O)C1=CC(OCC(F)(F)F)=CC=C1OCC(F)(F)F

CAS DataBase Reference

35480-52-5(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36-36/37/39

Hazard Note 

Irritant

HS Code 

2918999090

2,5-Bis(2,2,2-trifluoroethoxy)benzoic acid Usage And Synthesis

Chemical Properties

White to Off-White Solid

Uses

Flecainide Acetate Impurity D.

Uses

2,5-Bis(2,2,2-trifluoroethoxy)benzoic acid has been used in a variety of scientific research applications. It has been used as a reagent in the synthesis of organic compounds such as β-trifluoromethylbenzyl alcohols and β-trifluoromethylbenzyl chlorides. It has also been used as a catalyst in the synthesis of organic compounds such as α-trifluoromethylbenzyl alcohols and α-trifluoromethylbenzyl chlorides. Additionally, it has been used as a starting material in the synthesis of trifluoromethylated heterocyclic compounds such as thiazoles, oxazoles, and thiophenes.

Synthesis

Example 1: At room temperature, 300 mL of tetrahydrofuran (THF) was added to a reaction vial and 84.7 g of potassium tert-butanolate was added with stirring. Subsequently, 76.0 g of 2,2,2-trifluoroethanol was slowly added dropwise to the reaction mixture, controlling the reaction temperature to not exceed 35 °C. After the dropwise addition, the reaction mixture was continued to be stirred and then 29.6 g of 5-bromo-2-chlorobenzoic acid was added. Next, 27.3 g of copper (I) bromide was added and the reaction mixture was heated to reflux. After 43 hours of reaction, the mixture was cooled to 5 °C and slowly poured into dilute hydrochloric acid. The organic and aqueous phases were separated. The solvent was removed by distillation, during which the product gradually precipitated. 100 mL of water was added to the residue and the solid product was collected by filtration. To purify the product, the crude product was dissolved in methyl tertiary butyl ether (MTB ether), filtered through a neutral alumina column to remove insoluble components, and subsequently evaporated to remove the solvent. Finally, 2,5-bis(2,2,2-trifluoroethoxy)benzoic acid was recrystallized by solvent recrystallization in ethanol/water mixture to give 2,5-bis(2,2,2-trifluoroethoxy)benzoic acid in 45% yield. The product had a melting point of 120-122°C and was analyzed by high performance liquid chromatography (HPLC) with a purity greater than 98%.

References

[1] Patent: US2003/176721, 2003, A1

2,5-Bis(2,2,2-trifluoroethoxy)benzoic acid(35480-52-5)Related Product Information

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