Ethyl diethoxyphosphinylformate Chemical Properties

Boiling point:

135 °C12 mm Hg(lit.)

Density 

1.11 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.423(lit.)

Flash point:

>230 °F

storage temp. 

Store below +30°C.

solubility 

Chloroform (Slightly), Methanol (Slightly)

color 

Colorless to Almost colorless

Specific Gravity

1.11

BRN 

1781949

Stability:

Moisture Sensitive

CAS DataBase Reference

1474-78-8(CAS DataBase Reference)

NIST Chemistry Reference

Phosphinecarboxylic acid, diethoxy-, ethyl ester, oxide(1474-78-8)

EPA Substance Registry System

Phosphinecarboxylic acid, diethoxy-, ethyl ester, oxide (1474-78-8)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38-43

Safety Statements 

24/25-36/37-26-37-24

WGK Germany 

3

TSCA 

Yes

HS Code 

2931 39 90

MSDS

• Language:English Provider:Ethyl diethoxyphosphinylformate
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

Ethyl diethoxyphosphinylformate Usage And Synthesis

Chemical Properties

Clear colorless to slightly yellow liquid

Uses

Diethyl (Ethoxycarbonyl)phosphonate is an impurity in the synthesis of Foscarnet (F727400), an inhibitor of viral DNA polymerase and reverse transcriptase. Foscarnet is used as an antiviral.

General Description

for synthesis

Purification Methods

Dissolve it in Et2O, shake this with H2O (to remove any trace of NaCl impurity), dry (Na2SO4), evaporate and distil it using an efficient fractionating column. [Nylén Chem Ber 57 1035 1924, Reetz et al. J Am Chem Soc 77 3813 1955, Monson Advanced Organic Synthesis Academic Press p 89 1972, Beilstein 3 II 103.]

Ethyl diethoxyphosphinylformate(1474-78-8)Related Product Information

• Tripropyl orthoformate
• Methyldiethoxyphosphine
• ETHYL METHYLPHOSPHINATE
• TRIMETHYL PHOSPHONOFORMATE
• Diethyl (hydroxymethyl)phosphonate
• Foscarnet
• ETHYL METHYLPHOSPHONIC ACID
• METHYLPHOSPHONIC ACID
• Ethyl diethoxyphosphinylformate
• Diethyl methylphosphonate
• METHOXY CARBONYL PHOSPHONIC ACID
• PhosphonoMethanol
• METHYL METHYLPHOSPHONIC ACID
• Dimethyl methylphosphonate
• Dimethyl hydroxymethylphosphonate