N-(2-HYDROXYPROPYL)METHACRYLAMIDE
N-(2-HYDROXYPROPYL)METHACRYLAMIDE Basic information
- Product Name:
- N-(2-HYDROXYPROPYL)METHACRYLAMIDE
- Synonyms:
-
- N-(2-HYDROXYPROPYL)METHACRYLAMIDE
- N-(2-Hydroxypropyl)-2-methyl-prop-2-enamide
- N-(2-Hydroxypropyl)-2-methyl-prop-2-enamide AldrichCPR
- 2-Hydroxypropyl methacrylamide 99% (GC)
- 2-Hydroxypropyl methacrylamide
- 2-Propenamide,N-(2-hydroxypropyl)-2-methyl-
- N-(2-HYDROXYPROPYL)METHACRYLAMID
- High purity CAS 21442-01-3 N-(2-HYDROXYPROPYL)METHACRYLAMIDE in stock
- CAS:
- 21442-01-3
- MF:
- C7H13NO2
- MW:
- 143.18
- Product Categories:
-
- monomer
- Mol File:
- 21442-01-3.mol
N-(2-HYDROXYPROPYL)METHACRYLAMIDE Chemical Properties
- Melting point:
- 67.92°C
- Boiling point:
- 321.2±34.0 °C(Predicted)
- Density
- 1.002 g/mL ((predicted))
- storage temp.
- 2-8°C
- solubility
- Soluble in DMSO
- pka
- 14.43±0.20(Predicted)
- form
- powder
- color
- White to off-white
- InChI
- 1S/C7H13NO2/c1-5(2)7(10)8-4-6(3)9/h6,9H,1,4H2,2-3H3,(H,8,10)
- InChIKey
- OKPYIWASQZGASP-UHFFFAOYSA-N
- SMILES
- CC(O)CNC(=O)C(C)=C
Safety Information
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
- WGK Germany
- 3
- HS Code
- 2924297099
- Storage Class
- 11 - Combustible Solids
N-(2-HYDROXYPROPYL)METHACRYLAMIDE Usage And Synthesis
Description
N-(2-hydroxypropyl)methacrylamide (HPMA) is an important hydrophilic monomer. Due to the non-toxic, non-immunogenic properties and prolonged circulation time of both its homopolymers and copolymers, it is widely employed in the preparation of PHPMA copolymers (a polymer-drug conjugate) for use in the biopharmaceutical industry. For instance, poly(HPMA-co-MA-GFLG-doxorubicin) represents the first intravenous tumour-targeting polymeric prodrug to enter clinical trials. HPMA polymers and copolymers are also employed in the fabrication of biocompatible medical materials such as hydrogels[1].
Uses
Monomers to synthesize biocompetible polymers and copolymers for drug carriers, protein conjugates and hydrogels in biomedical applications.
in vivo
At 5 mg/kg body weight drug equivalent dose, all N-(2-Hydroxypropyl)methacrylamide copolymer-drug conjugates which contained lysosomally degradable side chains shows significant in vivo antileishmanial activity (>99% inhibition)[1].
References
[1] NGUYEN N H, RODRIGUEZ-EMMENEGGER C, BRYNDA E, et al. SET-LRP of N-(2-hydroxypropyl)methacrylamide in H2O†[J]. Polymer Chemistry, 2013, 8: 2424-2427. DOI:10.1039/C3PY00220A.
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