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4-Pyrazoleboronic acid pinacol ester

Basic information Safety Supplier Related

4-Pyrazoleboronic acid pinacol ester Basic information

Product Name:
4-Pyrazoleboronic acid pinacol ester
Synonyms:
  • 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole,min.97%
  • 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, min. 97%
  • 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole4-Pyrazoleboronic acid pinacol ester
  • 4-Pyrazoleboronic acid pinacol ester,97%
  • 4-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)pyrazole
  • 4-Pyrazoleboronic acid pinaol ester
  • 1H-Pyrazole, 4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-
  • 4-(tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
CAS:
269410-08-4
MF:
C9H15BN2O2
MW:
194.04
EINECS:
629-131-7
Product Categories:
  • organic or inorganic borate
  • Pyrazole series
  • API intermediates
  • Boronic acid
  • OLED materials,pharm chemical,electronic
  • 269410-08-4
Mol File:
269410-08-4.mol
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4-Pyrazoleboronic acid pinacol ester Chemical Properties

Melting point:
142-146 °C (lit.)
Boiling point:
335.4±15.0 °C(Predicted)
Density 
1.09±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
DMSO, Ethyl Acetate, Methanol
pka
13.36±0.50(Predicted)
form 
Powder
color 
Off-white to tan
Water Solubility 
insoluble
InChIKey
TVOJIBGZFYMWDT-UHFFFAOYSA-N
CAS DataBase Reference
269410-08-4(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xi,F
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
Hazard Note 
Irritant/Flammable
TSCA 
No
HS Code 
29331990

MSDS

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4-Pyrazoleboronic acid pinacol ester Usage And Synthesis

Chemical Properties

Off-white to tan powder

Uses

4-Pyrazoleboronic Acid Pinacol Ester is used in the preparation of Rho kinase (ROCK) inhibitors as wella s other biologically active compounds.

Uses

1H-Pyrazole-4-boronic acid pinacol ester is a useful reagent for Suzuki-Miyaura cross-couplings as well as Ruthenium-catalyzed asymmetric hydrogenation. It is also used as reagent for preparing VEGF, Aurora, RHO (ROCK), Janus Kinase 2, c-MET, ALK, S-nitrsoflutathione reductase, CDC7, Acetyl-CoA carboxylase inhibitors as well as other biologically active compounds.

Uses

Reagent used for

  • Suzuki-Miyaura cross-couplings
  • Ruthenium-catalyzed asymmetric hydrogenation

Reagent used in preparation of inhibitors of many highly significant therapeutic enzymes and kinases containing the privileged scaffold pyrazole, including
  • VEGF
  • Aurora
  • Rho (ROCK)
  • Janus Kinase 2 (JAK)
  • c-MET
  • ALK
  • S-nitrosoglutathione reductase
  • CDC7
  • Acetyl-CoA carboxylase
  • Prosurvival Bcl-2 protein
  • Viral RNA-Dependent RNA polymerase
  • Long Chain Fatty Acid Elongase 6
  • PI3
  • AKT
  • Chk1
  • Protein Kinase B

4-Pyrazoleboronic acid pinacol esterSupplier

AllyChem Co., Ltd. Gold
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