T-2 TOXIN Chemical Properties

Melting point:

151.5℃

alpha 

D26 +15° (c = 2.58 in ethanol)

Boiling point:

489.35°C (rough estimate)

Density 

1.1942 (rough estimate)

refractive index 

1.6230 (estimate)

Flash point:

2 °C

storage temp. 

−20°C

solubility 

DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml; Ethanol: 20 mg/ml

form 

powder

pka

13.24±0.70(Predicted)

color 

white

Merck 

13,9872

IARC

3 (Vol. 31, Sup 7) 1987

Safety Information

Hazard Codes 

T+,T,Xn,F

Risk Statements 

26/27/28-38-36-20/21/22-11

Safety Statements 

28-36/37-45-36-26-16-36/37/39-22

RIDADR 

UN 3462 6.1/PG 1

WGK Germany 

3

RTECS 

YD0100000

F 

10-21

HazardClass 

6.1(a)

PackingGroup 

I

HS Code 

29329990

Hazardous Substances Data

21259-20-1(Hazardous Substances Data)

Toxicity

LD50 orally in female rats: 4.0 mg/kg (Marasas); LD50 (mg/kg) in mice: 5.2 i.p., 4.2 i.v.; in rats: 7.0 intragastric, 0.9-1.3 i.p., 0.9 i.v., 2.0 s.c.; in guinea pigs: 3.0-4.0 orally, 5.3 intragastric, 1.0 i.m., 1.0-2.0 i.v., 1.0-2.0 s.c.; in pigs: 5.0 orally, 3.0 i.v. (Yagen, Bailer)

MSDS

• Language:English Provider:SigmaAldrich

T-2 TOXIN Usage And Synthesis

Description

T-2 toxin is a trichothecene mycotoxin that has been found in Fusarium. It binds to and inhibits peptidyltransferase in the 60S ribosomal subunit, inducing a ribotoxic stress response that triggers JNK and p38 MAPK signaling. T-2 toxin (3 nM) decreases toll-like receptor expression and LPS-induced production of IL-1β, TNF-α, and nitric oxide (NO) in, and is cytotoxic to (IC₅₀ = 19.47), primary pig alveolar macrophages (PAMs). In vivo, T-2 toxin induces production of reactive oxygen species (ROS), lipid peroxidation, and glutathione (GSH) depletion in mouse brain and is lethal to mice (LD₅₀s = 1.54-5.94 mg/kg). It also induces hepatocyte apoptosis and dyslipidemias in mice. T-2 toxin has been found in Fusarium-infected wheat, barley, and rice crops both in fields and in storage.

Chemical Properties

White powder

Uses

T-2 Toxin is a tricothecene mycotoxin produced by fungi of the genus Fusarium. T-2 Toxin induces DNA damage and cell death on prolonged administration.

Definition

ChEBI: T-2 toxin is a trichothecene mycotoxin produced by fungi of the genus Fusarium. It is a common contaminant in food and feedstuffs of cereal origin and is known to cause a range of toxic effects in humans and animals. It has a role as a mycotoxin, a cardiotoxic agent, a neurotoxin, an environmental contaminant, an apoptosis inducer, a DNA synthesis inhibitor and a fungal metabolite. It is a trichothecene, an acetate ester and an organic heterotetracyclic compound. It is functionally related to a HT-2 toxin.

General Description

T-2 Toxin is found to be a potent trichothecene mycotoxin produced by the genus fusarium fungi in feedstuffs and cereal grains.

Safety Profile

Poison by ingestion, intramuscular, subcutaneous, intraperitoneal, intracerebral, and intravenous routes. Moderately toxic by inhalation. Experimental teratogenic and reproductive effects. A skin irritant. Questionable carcinogen with experimental neoplastigenic data. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.

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