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T-2 TOXIN

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T-2 TOXIN Basic information

Product Name:
T-2 TOXIN
Synonyms:
  • 4β,15-Diacetoxy-8α-(3-Methylbutyryloxy)- 12,13-epoxytrichothec-9-en-3α-ol
  • 8α-(3-Methylbutyryloxy)-4β,15- diacetoxyscirp-9-en-3α-ol
  • T-2 LienoMycin
  • T-2 Toxin, froM FusariuM tricinctuM
  • T-2 Toxin, 99%, from Fusarium tricinctum
  • 12,13-epoxytrichothec-9-ene-3-alpha,4-beta,8-alpha,15-tetrol4,15-diacetate8
  • 12,13-trichothecene
  • 3alpha-Hydroxy-4beta,15-diacetoxy-8alpha(3-methylbutyryloxy)-12,13-epoxy-trichothec-9-ene
CAS:
21259-20-1
MF:
C24H34O9
MW:
466.53
EINECS:
244-297-7
Mol File:
21259-20-1.mol
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T-2 TOXIN Chemical Properties

Melting point:
151.5℃
alpha 
D26 +15° (c = 2.58 in ethanol)
Boiling point:
489.35°C (rough estimate)
Density 
1.1942 (rough estimate)
refractive index 
1.6230 (estimate)
Flash point:
2 °C
storage temp. 
−20°C
solubility 
DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml; Ethanol: 20 mg/ml
form 
powder
pka
13.24±0.70(Predicted)
color 
white
Merck 
13,9872
IARC
3 (Vol. 31, Sup 7) 1987
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Safety Information

Hazard Codes 
T+,T,Xn,F
Risk Statements 
26/27/28-38-36-20/21/22-11
Safety Statements 
28-36/37-45-36-26-16-36/37/39-22
RIDADR 
UN 3462 6.1/PG 1
WGK Germany 
3
RTECS 
YD0100000
10-21
HazardClass 
6.1(a)
PackingGroup 
I
HS Code 
29329990
Hazardous Substances Data
21259-20-1(Hazardous Substances Data)
Toxicity
LD50 orally in female rats: 4.0 mg/kg (Marasas); LD50 (mg/kg) in mice: 5.2 i.p., 4.2 i.v.; in rats: 7.0 intragastric, 0.9-1.3 i.p., 0.9 i.v., 2.0 s.c.; in guinea pigs: 3.0-4.0 orally, 5.3 intragastric, 1.0 i.m., 1.0-2.0 i.v., 1.0-2.0 s.c.; in pigs: 5.0 orally, 3.0 i.v. (Yagen, Bailer)

MSDS

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T-2 TOXIN Usage And Synthesis

Description

T-2 toxin is a trichothecene mycotoxin that has been found in Fusarium. It binds to and inhibits peptidyltransferase in the 60S ribosomal subunit, inducing a ribotoxic stress response that triggers JNK and p38 MAPK signaling. T-2 toxin (3 nM) decreases toll-like receptor expression and LPS-induced production of IL-1β, TNF-α, and nitric oxide (NO) in, and is cytotoxic to (IC50 = 19.47), primary pig alveolar macrophages (PAMs). In vivo, T-2 toxin induces production of reactive oxygen species (ROS), lipid peroxidation, and glutathione (GSH) depletion in mouse brain and is lethal to mice (LD50s = 1.54-5.94 mg/kg). It also induces hepatocyte apoptosis and dyslipidemias in mice. T-2 toxin has been found in Fusarium-infected wheat, barley, and rice crops both in fields and in storage.

Chemical Properties

White powder

Uses

T-2 Toxin is a tricothecene mycotoxin produced by fungi of the genus Fusarium. T-2 Toxin induces DNA damage and cell death on prolonged administration.

Definition

ChEBI: T-2 toxin is a trichothecene mycotoxin produced by fungi of the genus Fusarium. It is a common contaminant in food and feedstuffs of cereal origin and is known to cause a range of toxic effects in humans and animals. It has a role as a mycotoxin, a cardiotoxic agent, a neurotoxin, an environmental contaminant, an apoptosis inducer, a DNA synthesis inhibitor and a fungal metabolite. It is a trichothecene, an acetate ester and an organic heterotetracyclic compound. It is functionally related to a HT-2 toxin.

General Description

T-2 Toxin is found to be a potent trichothecene mycotoxin produced by the genus fusarium fungi in feedstuffs and cereal grains.

Safety Profile

Poison by ingestion, intramuscular, subcutaneous, intraperitoneal, intracerebral, and intravenous routes. Moderately toxic by inhalation. Experimental teratogenic and reproductive effects. A skin irritant. Questionable carcinogen with experimental neoplastigenic data. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.

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