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Pimobendan

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Pimobendan Basic information

Product Name:
Pimobendan
Synonyms:
  • PIMOBENDAN
  • 3(2H)-Pyridazinone,4,5-dihydro-6-[2-(4-methoxyphenyl)-1H-benzimidazol-6-yl]-5-methyl-
  • 4,5-Dihydro-6-[2-(4-methoxyphenyl)-1H-benzimidazol-5-y1]-5-methyl-3(2H)-pyridazinone
  • PIMOBENDANE HCL
  • Pimobendam
  • 3(2H)-Pyridazinone, 4,5-dihydro-6-2-(4-methoxyphenyl)-1H-benzimidazol-5-yl-5-methyl-
  • 3(2H)-Pyridazinone, 4,5-dihydro-6-[2-(4-methoxyphenyl)-1H-benzimidazol-5-yl]-5-methyl- (9CI)
  • dl-Pimobendan
CAS:
74150-27-9
MF:
C19H18N4O2
MW:
334.37
EINECS:
640-420-7
Product Categories:
  • Aromatics
  • Heterocycles
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Inhibitor
  • Acardi, pimobendane
Mol File:
74150-27-9.mol
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Pimobendan Chemical Properties

Melting point:
approximate 243℃ (dec.)
Density 
1.36
storage temp. 
2-8°C
solubility 
DMSO: soluble5mg/mL, clear (warmed)
pka
10.55±0.10(Predicted)
form 
powder
color 
white to beige
InChIKey
GLBJJMFZWDBELO-UHFFFAOYSA-N
CAS DataBase Reference
74150-27-9(CAS DataBase Reference)
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Safety Information

RIDADR 
UN 2811 6.1 / PGIII
HS Code 
2933995300
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Pimobendan Usage And Synthesis

Description

Pimobendan, a novel cardiotonic vasodilator, was introduced in Japan for the treatment of acute and mild to moderate chronic heart failure. It is a phosphodiesterase Ⅲ inhibitor and is able to enhance sensitization of myocardial contractile regulatory protein to calcium ions. The combination of these effects contribute to its inotropic activity. In patients with severe congestive heart failure, orally administered pimobendan improves cardiac index, stroke volume index, pulmonary wedge pressure, and systemic and pulmonary vascular resistance. Pimobendan is reported to be well tolerated and largely devoid of the proarrhythmic effects of classical phosphodiesterase Ill inhibitors. Studies also suggested that combination of the inotropic agent pimobendan with an ACE inhibitor such as enalapril may be superior to monotherapy for heart failure patients.

Chemical Properties

White Solid

Originator

Boehringer lngelhelm (Germany)

Uses

antiviral

Uses

Pimobendan is a cardiotonic agent. The study of the cardiotonic mechanism of Pimobendan using ventricular muscles from rabbits and guinea pigs suggests that Pimobendan acts by inhibiting phosphodiesterase III and potassium channel. The potent venodilating action of Pimobendan makes it a suitable treatment option for patients with congestive heart failure (CHF) as it also improves systemic vasoconstriction.

Uses

Pimobendan is a selective inhibitor of PDE3 with IC50 of 0.32 μM

brand name

Acardl

Veterinary Drugs and Treatments

Pimobendan is used to treat dogs with congestive heart failure secondary to dilated cardiomyopathy or chronic mitral valve insufficiency (CMVI).

PimobendanSupplier

Suzhou Pharmaceutical Technology co.,ltd Gold
Tel
Email
cindy.hoo@tcsindustry.com
China Shenyang Tyschem CO. ,LTD Gold
Tel
;24-83607930-
Email
sales@honghuchem.com;tongyuansu@126.com
Ningbo Nuobai Pharmaceutical Co., Ltd. Gold
Tel
0574-87684611;18758416982
Email
Fisheryu@nbpharm.com
Hebei Runmin Fine Chemical Co., Ltd. Gold
Tel
18032696490
Email
wanmin.jiang@hebeirm.com
Shanghai Mixiu Chemical Co., Ltd. Gold
Email
eileen@shmychem.com