Methyl 5-thiazolecarboxylate Chemical Properties

Melting point:

68-69°C

Boiling point:

87-90°C (10 mmHg)

Density 

1.45

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

pka

0.80±0.10(Predicted)

Appearance

Off-white to light yellow Solid

CAS DataBase Reference

14527-44-7(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn

Risk Statements 

36/37/38-22

Safety Statements 

26-36/37/39

Hazard Note 

Harmful

HS Code 

2934100090

Methyl 5-thiazolecarboxylate Usage And Synthesis

Synthesis

The general procedure for the synthesis of methyl 5-thiazolecarboxylate from methyl 2-aminothiazole-5-carboxylate was as follows: a mixture of 2.25 g of isoamyl nitrite with 10 mL of dioxane was stirred at 80 °C under nitrogen protection. Subsequently, a 20 mL dioxane solution containing 1.23 g of methyl 2-aminothiazole-5-carboxylate (g-3) was slowly added dropwise. After the dropwise addition was completed, the reaction mixture was refluxed for 2 hours. After the reaction was completed, it was cooled to room temperature and diluted by adding 30 mL of ethyl acetate. The organic phase was washed with saturated saline, dried over anhydrous sodium sulfate and concentrated under reduced pressure to remove the solvent. The crude product was purified by silica gel column chromatography to give 0.54 g (48% yield) of the target product methyl 5-thiazolecarboxylate (g-4).

References

[1] Patent: WO2003/97616, 2003, A1. Location in patent: Page/Page column 26

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