DL-TYROSINE METHYL ESTER HCL Chemical Properties

Melting point:

192-193°

storage temp. 

Inert atmosphere,2-8°C

Appearance

White to off-white Solid

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

DL-TYROSINE METHYL ESTER HCL Usage And Synthesis

Synthesis

Under argon protection, D,L-tyrosine (10.0 g, 55.1 mmol) was dissolved in methanol (88 mL) and the reaction system was cooled to 0°C. Subsequently, thionyl chloride (3.97 mL, 60.6 mmol) was added slowly and dropwise. Upon completion of the reaction, the reaction solution was concentrated under reduced pressure. The resulting crude product was purified by recrystallization from a solvent mixture of methanol (5 mL) and diethyl ether (80 mL) to afford the target product L-tyrosine methyl ester hydrochloride (10.8 g).

References

[1] Acta Chimica Academiae Scientiarum Hungaricae, 1981, vol. 107, # 1, p. 7 - 9
[2] European Journal of Medicinal Chemistry, 1986, vol. 21, # 4, p. 333 - 338
[3] Chemical Communications, 2008, # 30, p. 3528 - 3530
[4] Advanced Synthesis and Catalysis, 2012, vol. 354, # 17, p. 3327 - 3332
[5] Angewandte Chemie - International Edition, 2013, vol. 52, # 49, p. 12942 - 12945

DL-TYROSINE METHYL ESTER HCL(68697-61-0)Related Product Information

• DL-Tyrosine
• DL-Tryptophan
• L-TYROSINE ETHYL ESTER HYDROCHLORIDE
• O-Benzyl-L-tyrosine methyl ester hydrochloride
• H-TYR(TBU)-OTBU HCL
• H-D-TYR-OME HCL
• D-TYROSINE ETHYL ESTER HYDROCHLORIDE
• O-Benzyl-L-tyrosine benzyl ester hydrochloride
• Methyl L-tyrosinate hydrochloride
• H-3,5-DIIODO-TYR-OME HCL
• 3,5-Diiodo-L-tyrosine ethyl ester hydrochloride
• L-Tyrosinebutylesterhydrochloride
• L-3,4-DIHYDROXYPHENYLALANINE METHYL ESTER HYDROCHLORIDE
• H-GLY-TYR-OET HCL
• CHLOROAC-TYR-OET
• H-ALA-TYR-OET HCL
• DL-TYROSINE METHYL ESTER HCL
• ALPHA-METHYL-DL-TYROSINE METHYL ESTER HYDROCHLORIDE