3-Picoline-N-oxide Chemical Properties

Melting point:

37-39 °C(lit.)

Boiling point:

150 °C15 mm Hg(lit.)

Density 

1.13

refractive index 

1.5444 (estimate)

Flash point:

>230 °F

storage temp. 

Sealed in dry,Room Temperature

solubility 

>2000g/l

pka

pK1:10.921(+1) (25°C)

form 

Crystalline Low Melting Mass

color 

Pale yellow to brown

Water Solubility 

soluble

Sensitive 

Hygroscopic

BRN 

106327

CAS DataBase Reference

1003-73-2(CAS DataBase Reference)

NIST Chemistry Reference

Pyridine, 3-methyl-, 1-oxide(1003-73-2)

EPA Substance Registry System

Pyridine, 3-methyl-, 1-oxide (1003-73-2)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-37/39-24/25-36

WGK Germany 

1

RTECS 

UT5799000

F 

3-10

TSCA 

Yes

HS Code 

29333990

Toxicity

mouse,LD50,intraperitoneal,1689mg/kg (1689mg/kg),Toxicon. Vol. 23, Pg. 815, 1985.

MSDS

• Language:English Provider:3-Methylpyridine-N-oxide
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

3-Picoline-N-oxide Usage And Synthesis

Chemical Properties

PALE YELLOW TO BROWN CRYSTALLINE LOW MELTING MASS

Uses

An intermediate in the preparation of nicotine derivatives.

Purification Methods

Purify the N-oxide by careful fractionation in vacuo. The distillate remains supercooled for several days before solidifying. It is a slightly hygroscopic solid which could melt in the hand. The picrate has m 149-151o (from EtOH). [Taylor & Corvetti Org Synth Coll Vol IV 654 1963, IR: Katritzky et al. J Chem Soc 3680 1959, Jaffé & Doak J Am Chem Soc 77 4441, 4481 1955, Boekelheide & Linn J Am Chem Soc 76 1286 1954]. [Beilstein 20 III/IV 2719, 20/5 V 517.]

3-Picoline-N-oxide(1003-73-2)Related Product Information

• Cuprous oxide
• 3-Aminopyridine
• 2,6-Lutidine
• 2,4,6-Collidine
• 2-Chloro-5-chloromethylpyridine
• Iron oxide
• Pyridine-N-oxide
• NITRIC OXIDE
• ETHYLENE OXIDE
• Propylene oxide
• Azamethiphos
• 3-Picoline
• Zinc oxide
• 4-Methylpyridine
• Magnesium oxide
• (Diethoxymethyl)diphenylphosphine oxide
• 7-CHLORO-1,3-DIHYDRO-5-PHENYL-2H-1,4-BENZODIAZEPINE-2-ONE-4-OXIDE
• NITROUS OXIDE