4-Nitropyridine N-oxide Chemical Properties

Melting point:

159-162 °C (lit.)

Boiling point:

256.56°C (rough estimate)

Density 

1.5657 (rough estimate)

refractive index 

1.4800 (estimate)

storage temp. 

Inert atmosphere,Room Temperature

solubility 

soluble in DMSO

pka

-1.37±0.10(Predicted)

form 

Crystals or Powder

color 

Yellow to brown

Water Solubility 

insoluble

BRN 

124331

CAS DataBase Reference

1124-33-0(CAS DataBase Reference)

NIST Chemistry Reference

Pyridine-1-oxide, 4-nitro-(1124-33-0)

EPA Substance Registry System

4-Nitropyridine-1-oxide (1124-33-0)

Safety Information

Hazard Codes 

T

Risk Statements 

25-36/37/38-40-23/24/25

Safety Statements 

26-45-37/39-28A-36-22

RIDADR 

UN 2811 6.1/PG 3

WGK Germany 

3

RTECS 

UT6380000

TSCA 

Yes

HazardClass 

6.1

PackingGroup 

III

HS Code 

29333999

Hazardous Substances Data

1124-33-0(Hazardous Substances Data)

Toxicity

LD50 orl-rat: 107 mg/kg JWMAA9 29,830,65

MSDS

• Language:English Provider:4-Nitropyridine N-oxide
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

4-Nitropyridine N-oxide Usage And Synthesis

Preparation

pyridine is reluctant to undergo electrophilic nitration, pyridine-N-oxide is activated to electrophilic attack and nitration gives 4-nitropyridine-N-oxidel.

Chemical Properties

white to light yellow crystal

Uses

4-Nitropyridine N-oxide may be used in the preparation of several 4-substituted pyridine-N-oxides and pyridines.

Uses

The N-oxide derivative of a nitrated pyridine that has been shown to inhibit Na,K-ATPase activity. 4-Nitropyridine N-Oxide is a quorum sensing inhibitor.

General Description

Solid.

Air & Water Reactions

May be deliquescent.

Reactivity Profile

Aromatic nitro compounds range from slight to strong oxidizing agents. If mixed with reducing agents, including hydrides, sulfides and nitrides, they may begin a vigorous reaction.

Health Hazard

High toxicity via oral exposure.

Fire Hazard

When heated to decomposition, 4-Nitropyridine N-oxide emits very toxic fumes of nitrogen oxides. Avoid decomposing heat.

Safety Profile

Poison by ingestion and skincontact. Questionable carcinogen with experimentaltumorigenic data. Mutation data reported. Mixtures withdiethyl-1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylateexplode when heated above 130°C. When heated todecompositio

4-Nitropyridine N-oxide(1124-33-0)Related Product Information

• 4-Nitropyridine
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• Cuprous oxide
• superoxide dismutase
• Iron oxide
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• ETHYLENE OXIDE
• Magnesium oxide
• NITRIC OXIDE
• (Diethoxymethyl)diphenylphosphine oxide
• 2-BROMO-4-NITROPYRIDINE 1-OXIDE,2-BROMO-4-NITROPYRIDINE N-OXIDE
• 3-BROMO-4-NITROPYRIDINE N-OXIDE, 98+%,3-BROMO-4-NITROPYRIDINE 1-OXIDE,3-BROMO-4-NITROPYRIDINE N-OXIDE
• NITROUS OXIDE
• 2,3-DIMETHYL-4-NITROPYRIDINE N-OXIDE,2,3-DIMETHYL-4-NITROPYRIDINE 1-OXIDE,2,3-Nimethyl-4-nitropyridine-N-oxide
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• 4-NITROQUINOLINE N-OXIDE
• 4-NITRO-2-PICOLINE N-OXIDE (2-METHYL-4-NITROPYRIDINE-N-OXIDE),2-METHYL-4-NITROPYRIDINE N-OXIDE,2-METHYL-4-NITROPYRIDINE 1-OXIDE