5,8,11-EICOSATRIYNOIC ACID Chemical Properties

Melting point:

70.5-71.5 °C

Boiling point:

473.8±40.0 °C(Predicted)

Density 

0.990±0.06 g/cm3(Predicted)

storage temp. 

−20°C

solubility 

Chloroform (Slightly), Methanol (Slightly)

form 

Off-white solid.

pka

4.61±0.10(Predicted)

color 

Pale Yellow to Pale Beige

Stability:

Light Sensitive

Safety Information

WGK Germany 

3

MSDS

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5,8,11-EICOSATRIYNOIC ACID Usage And Synthesis

Uses

ETI is a leukotriene antagonist and selective 5-LO (5-lipoxygenase) inhibitor.

Definition

ChEBI: A C20 polyunsaturated fatty acid having three triple bonds in the 5-, 8- and 11-positions.

Biological Activity

5,8,11-eicosatriynoic acid is a selective inhibitor of lipoxygenases with id50 values of 24 μm and 340 μm for n-8 lipoxygenase and fatty acid cycle-oxygenase , respectively[1][2].fatty acid cycle-oxygenase and n-8 lipoxygenase catalyze the initial reactions which lead to the formation of three major arachidonic acid metabolites in human platelets. in several tissues, these two enzymes act concomitantly on arachidonic acid [1].5,8,11-eicosatriynoic acid (5,8,11-et) is a selective inhibitor of lipoxygenases with id50 values of 24 μm and 340 μm for n-8 lipoxygenase and fatty acid cycle-oxygenase, respectively. 5,8,11-eicosatriynoic acid was useful for studies on physiological and pathophysiological roles of 12 l-hydroxy-5,8,10,14-eicosatetraenoic acid formation in various tissues [1]. in mouse mastocytoma cells, 5,8,11-eicosatriynoic acid inhibited a23187 and l-cysteine induced leukotriene c (ltc4) biosynthesis with id50 value of 5 μm [2].

References

[1]. hammarstrm s. selective inhibition of platelet n-8 lipoxygenase by 5,8,11-eicosatriynoic acid. biochim biophys acta. 1977 jun 22;487(3):517-9.
[2]. orning l, hammarstrm s. inhibition of leukotriene c and leukotriene d biosynthesis. j biol chem. 1980 sep 10;255(17):8023-6.

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