VESNARINONE
VESNARINONE Basic information
- Product Name:
- VESNARINONE
- Synonyms:
-
- VESNARINONE
- Arkin
- Piteranometozine
- OPC 8212
- 6-[4-(3,4-Dimethoxybenzoyl)-1-piperazinyl]-3,4-dihydro-2(1H)-quinolinone
- 2(1H)-Quinolinone, 6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-3,4-dihydro-
- 0PC-8212
- 3,4-Dihydro-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-2(1H)-quinolinone
- CAS:
- 81840-15-5
- MF:
- C22H25N3O4
- MW:
- 395.45
- Mol File:
- 81840-15-5.mol
VESNARINONE Chemical Properties
- Melting point:
- 238.1-239.5° (Tominaga); mp 238.1-239.8° (Shimizu)
- Boiling point:
- 519.41°C (rough estimate)
- Density
- 1.2414 (rough estimate)
- refractive index
- 1.6500 (estimate)
- storage temp.
- Store at -20°C
- solubility
- DMSO:9.84(Max Conc. mg/mL);24.88(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.26(Max Conc. mM)
DMF:3.0(Max Conc. mg/mL);7.59(Max Conc. mM) - form
- A crystalline solid
- pka
- 2.86(at 25℃)
- color
- White to off-white
VESNARINONE Usage And Synthesis
Description
Vesnarinone is a new orally-active positive inotropic agent introduced for the treatment of congestive heart failure. It exerts a positive inotropic effect on the heart and has a peripheral vasodilatory effect. Vesnarinone is claimed not to affect heart rate or aggravate arrhythmia.
Description
Vesnarinone is an inhibitor of phosphodiesterase 3 (PDE3; IC50s = 10.7 and 13.2 μM for PDE3A and PDE3B, respectively). It also inhibits ether-a-go-go-related gene 1 (ERG1) channels (IC50 = 1.1 μM in HEK293T cells expressing human ERG1). Vesnarinone (3-300 μM) increases contractile tension in isolated ventricular muscles of dog, cat, rabbit, and guinea pig in a dose-dependent manner. Oral and i.v. administration of vesnarinone increases right ventricular pressure with no effect on heart rate in dog models of tricuspid insufficiency- and pulmonary stenosis-induced congestive heart failure. It also increases contractility and coronary flow while decreasing heart rate in a guinea pig model of aortic stenosis-induced congestive heart failure. Formulations containing vesnarinone have been used for the treatment of congestive heart failure.
Originator
Otsuka (Japan)
Uses
Cardiotonic.
Definition
ChEBI: Arkin (TN) is an organic molecular entity.
brand name
Arkin (Otsuka America);Arkin-Z.
VESNARINONE Preparation Products And Raw materials
Raw materials
VESNARINONESupplier
- Tel
- sales@boylechem.com
- Tel
- 1-(800)-881-8210
- inquiries@lgmpharma.com
- Tel
- 021-58950125
- info@chemexpress.com
- Tel
- 021-58955995
- sales@medchemexpress.cn
- Tel
- 022-60688926
VESNARINONE(81840-15-5)Related Product Information
- MK-8931
- DOBUTAMINE
- Pimobendan
- Olprinone
- Losartan potassium
- (4-HYDROXY-PHENYL)-PIPERAZIN-1-YL-METHANONE
- ETHAMIVAN
- 1-(4-METHOXYBENZOYL)-PIPERAZINE
- VESNARINONE
- 1-[4-(4-AMINO-PHENYL)-PIPERAZIN-1-YL]-ETHANONE
- 6-AMINO-3,4-DIHYDRO-1H-QUINOLIN-2-ONE
- 6''-AMINO-1,2,3,4-TETRAHYDROQUINOLINE
- 4-(4-BENZYLPIPERAZINO)ANILINE
- (3-METHOXY-PHENYL)-PIPERAZIN-1-YL-METHANONE
- 2-METHYL-4-(4-METHYLPIPERAZIN-1-YL)ANILINE
- 1-(3-METHOXYBENZYL)PIPERAZINE
- 1-(4-METHOXYBENZYL)PIPERAZINE
- 1-(4-HYDROXYBENZOYL)-4-METHYL-PIPERAZINE