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VESNARINONE

Basic information Safety Supplier Related

VESNARINONE Basic information

Product Name:
VESNARINONE
Synonyms:
  • VESNARINONE
  • Arkin
  • Piteranometozine
  • OPC 8212
  • 6-[4-(3,4-Dimethoxybenzoyl)-1-piperazinyl]-3,4-dihydro-2(1H)-quinolinone
  • 2(1H)-Quinolinone, 6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-3,4-dihydro-
  • 0PC-8212
  • 3,4-Dihydro-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-2(1H)-quinolinone
CAS:
81840-15-5
MF:
C22H25N3O4
MW:
395.45
Mol File:
81840-15-5.mol
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VESNARINONE Chemical Properties

Melting point:
238.1-239.5° (Tominaga); mp 238.1-239.8° (Shimizu)
Boiling point:
519.41°C (rough estimate)
Density 
1.2414 (rough estimate)
refractive index 
1.6500 (estimate)
storage temp. 
Store at -20°C
solubility 
DMSO:9.84(Max Conc. mg/mL);24.88(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.26(Max Conc. mM)
DMF:3.0(Max Conc. mg/mL);7.59(Max Conc. mM)
form 
A crystalline solid
pka
2.86(at 25℃)
color 
White to off-white
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VESNARINONE Usage And Synthesis

Description

Vesnarinone is a new orally-active positive inotropic agent introduced for the treatment of congestive heart failure. It exerts a positive inotropic effect on the heart and has a peripheral vasodilatory effect. Vesnarinone is claimed not to affect heart rate or aggravate arrhythmia.

Description

Vesnarinone is an inhibitor of phosphodiesterase 3 (PDE3; IC50s = 10.7 and 13.2 μM for PDE3A and PDE3B, respectively). It also inhibits ether-a-go-go-related gene 1 (ERG1) channels (IC50 = 1.1 μM in HEK293T cells expressing human ERG1). Vesnarinone (3-300 μM) increases contractile tension in isolated ventricular muscles of dog, cat, rabbit, and guinea pig in a dose-dependent manner. Oral and i.v. administration of vesnarinone increases right ventricular pressure with no effect on heart rate in dog models of tricuspid insufficiency- and pulmonary stenosis-induced congestive heart failure. It also increases contractility and coronary flow while decreasing heart rate in a guinea pig model of aortic stenosis-induced congestive heart failure. Formulations containing vesnarinone have been used for the treatment of congestive heart failure.

Originator

Otsuka (Japan)

Uses

Cardiotonic.

Definition

ChEBI: Arkin (TN) is an organic molecular entity.

brand name

Arkin (Otsuka America);Arkin-Z.

VESNARINONE Preparation Products And Raw materials

Raw materials

VESNARINONESupplier

Shanghai Boyle Chemical Co., Ltd.
Tel
Email
sales@boylechem.com
LGM Pharma
Tel
1-(800)-881-8210
Email
inquiries@lgmpharma.com
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Email
info@chemexpress.com
MedChemexpress LLC
Tel
021-58955995
Email
sales@medchemexpress.cn
Zhengzhou Saifun Biotechnology Co., Ltd.
Tel
022-60688926