Diridavumab
Diridavumab Basic information
- Product Name:
- Diridavumab
- Synonyms:
-
- Diridavumab
- Research Grade Diridavumab(DVV03801)
- Research Grade Diridavumab
- CAS:
- 1393659-46-5
- MW:
- 0
- Mol File:
- Mol File
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Diridavumab Chemical Properties
- form
- Liquid
- color
- Colorless to light yellow
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Diridavumab Usage And Synthesis
Uses
Diridavumab is a monoclonal anti-HA stalk antibody. Diridavumab stabilizes the prefusion HA structure and prevents pH-dependent fusion of cellular and viral membranes in endosomes. Diridavumab can be used in research of H2 influenza virus[1].
in vivo
Diridavumab (CR6261; 1.7-15 mg/kg; i.p.; BALB/c mice with H2 influenza virus) protects mice against lethal H2 influenza virus in a dose-dependent manner[1].
| Animal Model: | BALB/c mice with H2 influenza virus[1] |
| Dosage: | 1.7, 5, or 15 mg/kg |
| Administration: | Intraperitoneal injection |
| Result: | Prevented mortality and decreased the percent weight loss. Decreased viral load, altered antigen distribution, and reduced the severity of airway inflammation. |
References
[1] Sutton TC, et, al. In Vitro Neutralization Is Not Predictive of Prophylactic Efficacy of Broadly Neutralizing Monoclonal Antibodies CR6261 and CR9114 against Lethal H2 Influenza Virus Challenge in Mice. J Virol. 2017 Nov 30;91(24):e01603-17. DOI:10.1128/JVI.01603-17
DiridavumabSupplier
ShangHai Biochempartner Co.,Ltd
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Guangzhou Hongyuan Chemical Co.,Ltd
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Wuhan Chemstan Biotechnology Co., Ltd.
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